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Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus.

Abstract : Nerve fibers containing activin-like immunoreactivity have been shown to be present within the area of the supraoptic nucleus. In this study, whole-cell patch-clamp recordings from supraoptic magnocellular neurosecretory cells were used to characterize the electrophysiological effects of this peptide. Nanomolar concentrations of recombinant activin-A caused the appearance of a voltage-independent current reversing near -40 mV. At resting potential, membrane depolarization caused by this current was sufficient to accelerate action potential discharge, suggesting that activin receptors expressed on magnocellular neurosecretory cells may play a role in the control of neurohypophysial hormone release.
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https://www.hal.inserm.fr/inserm-00000083
Contributor : Stéphane Oliet <>
Submitted on : Wednesday, March 29, 2006 - 12:27:17 PM
Last modification on : Thursday, June 18, 2020 - 12:32:04 PM

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  • HAL Id : inserm-00000083, version 1
  • PUBMED : 8547942

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Stéphane Oliet, Paul Plotsky, Charles Bourque. Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus.. J Neuroendocrinol, 1995, 7, pp.661-3. ⟨inserm-00000083⟩

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