Skip to Main content Skip to Navigation
Journal articles

Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons.

Abstract : Stretch-sensitive ion channels are ubiquitous, yet evidence of their role in mechanotransduction remains scarce. The presence of stretch-inactivated cation channels in supraoptic neurons is consistent with the osmoreceptor potentials regulating vasopressin release. However, whether osmosensitivity depends on mechanical gating and ion flux through stretch-inactivated channels is unknown. Here we report that changes in channel open probability associated either with modification of pipette pressure or with external osmolality selectivity result from variations in closed time. While channel mechanosensitivity and osmotically evoked changes in cell volume are not affected by gadolinium, similar concentrations of the lanthanide inhibit cation permeation through the single channels and macroscopic osmoreceptor potentials. Mechanotransduction through stretch-inactivated channels is therefore necessary for osmoreception in supraoptic neurons.
Document type :
Journal articles
Complete list of metadata
Contributor : Stéphane Oliet <>
Submitted on : Wednesday, March 29, 2006 - 12:19:39 PM
Last modification on : Thursday, June 18, 2020 - 12:32:04 PM


  • HAL Id : inserm-00000077, version 1
  • PUBMED : 8562082



Stéphane Oliet, Charles Bourque. Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons.. Neuron, Elsevier, 1996, 16, pp.175-81. ⟨inserm-00000077⟩



Record views