Bidirectional control of quantal size by synaptic activity in the hippocampus. - Archive ouverte HAL Access content directly
Journal Articles Science Year : 1996

Bidirectional control of quantal size by synaptic activity in the hippocampus.

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Abstract

Analysis of strontium-induced asynchronous release of quanta from stimulated synapses revealed that long-term potentiation and long-term depression in the CA1 region of the mammalian hippocampus are associated with an increase and a decrease, respectively, in quantal size. At a single set of synapses, the increase in quantal size seen with long-term potentiation was completely reversed by depotentiating stimuli. Long-term potentiation and depression are also associated with an increase and decrease, respectively, in the frequency of quantal events, consistent with an all-or-none regulation (up or down) of clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, a change in the release of transmitter, or both.
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Dates and versions

inserm-00000076 , version 1 (29-03-2006)

Identifiers

  • HAL Id : inserm-00000076 , version 1
  • PUBMED : 8638114

Cite

Stéphane H.R. Oliet, Robert C. Malenka, Roger A. Nicoll. Bidirectional control of quantal size by synaptic activity in the hippocampus.. Science, 1996, 271, pp.1294-7. ⟨inserm-00000076⟩

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