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Control of glutamate clearance and synaptic efficacy by glial coverage of neurons.

Abstract : Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutamate clearance, whether induced pharmacologically or associated with a relative decrease of glial coverage in the vicinity of synapses, affected transmitter release through modulation of presynaptic metabotropic glutamate receptors. Astrocytic wrapping of neurons, therefore, contributes to the regulation of synaptic efficacy in the central nervous system.
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https://www.hal.inserm.fr/inserm-00000059
Contributor : Stéphane Oliet Connect in order to contact the contributor
Submitted on : Wednesday, March 29, 2006 - 11:33:43 AM
Last modification on : Monday, May 9, 2022 - 11:58:07 AM

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Stéphane H.R. Oliet, Richard Piet, Dominique Paris-Poulain. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons.. Science, American Association for the Advancement of Science (AAAS), 2001, 292, pp.923-6. ⟨10.1126/science.1059162⟩. ⟨inserm-00000059⟩

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