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Journal articles
Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome.: Early thymic development in SOD1 transgenic mice.
Abstract : Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD.
Cited literature [55 references]
https://www.hal.inserm.fr/inserm-00000050
Contributor : Patrice Marche <>
Submitted on : Thursday, June 1, 2006 - 11:33:10 AM
Last modification on : Friday, May 1, 2020 - 1:37:36 AM
Long-term archiving on: : Saturday, April 3, 2010 - 9:09:29 PM
Contributor : Patrice Marche <>
Submitted on : Thursday, June 1, 2006 - 11:33:10 AM
Last modification on : Friday, May 1, 2020 - 1:37:36 AM
Long-term archiving on: : Saturday, April 3, 2010 - 9:09:29 PM