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Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome.: Early thymic development in SOD1 transgenic mice.

Julien Laurent 1 Evelyne Paly 2 Patrice Marche 1, * Jacqueline London 2, *
* Corresponding author
2 EA_3508 - Modèles de dérégulation génique : trisomie 21 et hyperhomocystéinémie
UPD7 - Université Paris Diderot - Paris 7 : EA_3508, CNRS - Centre National de la Recherche Scientifique : EA3508
Abstract : Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD.
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Submitted on : Thursday, June 1, 2006 - 11:33:10 AM
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Julien Laurent, Evelyne Paly, Patrice Marche, Jacqueline London. Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome.: Early thymic development in SOD1 transgenic mice.. Free Radical Biology and Medicine, Elsevier, 2006, 40 (11), pp.1971-1980. ⟨10.1016/j.freeradbiomed.2006.01.029⟩. ⟨inserm-00000050⟩

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