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Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.

Abstract : Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to and invasion of host surfaces. Flagellin is the structural protein that forms the major portion of flagellar filaments. Thus, flagellin consists of a conserved domain that is widespread in bacterial species and is dedicated to filament polymerization. Conversely, mammalian hosts detect the conserved domain on flagellin monomers through Toll-like receptor (TLR) 5, which triggers proinflammatory and adaptive immune responses. This review describes the relationships among flagellin molecular structure, bacterial virulence and host defenses, with special emphasis on mucosal tissues.
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https://www.hal.inserm.fr/inserm-00000046
Contributor : Jean-Claude Sirard Connect in order to contact the contributor
Submitted on : Wednesday, March 29, 2006 - 11:48:28 AM
Last modification on : Tuesday, April 17, 2018 - 3:10:01 PM
Long-term archiving on: : Monday, September 17, 2012 - 12:45:15 PM

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Hugo Cruz Ramos, Martin Rumbo, Jean-Claude Sirard. Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.. Trends Microbiol, 2004, 12 (11), pp.509-17. ⟨10.1016/j.tim.2004.09.002⟩. ⟨inserm-00000046⟩

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