Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

Abstract : The nature of dendritic cell(s) (DC[s]) that conditions efficient in vivo priming of CD8+ CTL after immunization via epithelial tissues remains largely unknown. Here, we show that myeloid DCs rapidly recruited by adjuvants into the buccal mucosa or skin are essential for CD8+ T cell crosspriming. Recruitment of circulating DC precursors, including Gr1+ monocytes, precedes the sequential accumulation of CD11c+ MHC class II+ DCs in dermis and epithelium via a CCR6/CCL20-dependent mechanism. Remarkably, a defect in CCR6, local neutralization of CCL20, or depletion of monocytes prevents in vivo priming of CD8+ CTL against an innocuous protein antigen administered with adjuvant. In addition, transfer of CCR6-sufficient Gr1+ monocytes restores CD8+ T cell priming in CCR6( degrees / degrees ) mice via a direct Ag presentation mechanism. Thus, newly recruited DCs likely derived from circulating monocytes are responsible for efficient crosspriming of CD8+ CTL after mucosal or skin immunization.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-00000041
Contributor : Jean-Claude Sirard Connect in order to contact the contributor
Submitted on : Sunday, June 25, 2006 - 10:29:51 PM
Last modification on : Saturday, June 25, 2022 - 9:20:01 PM

Links full text

Identifiers

Collections

Citation

Marie Le Borgne, Nathalie Etchart, Anne Goubier, Sergio A. Lira, Jean Claude Sirard, et al.. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.. Immunity, Elsevier, 2006, 24, pp.191-201. ⟨10.1016/j.immuni.2006.01.005⟩. ⟨inserm-00000041⟩

Share

Metrics

Record views

159