R. Petersen, G. Smith, S. Waring, R. Ivnik, E. Tangalos et al., Mild Cognitive Impairment, Archives of Neurology, vol.56, issue.3, pp.303-311, 1999.
DOI : 10.1001/archneur.56.3.303
URL : https://hal.archives-ouvertes.fr/inserm-00112038

B. Winblad, K. Palmer, M. Kivipelto, V. Jelic, L. Fratiglioni et al., Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment, Journal of Internal Medicine, vol.256, issue.3, pp.240-246, 2004.
DOI : 10.1111/j.1365-2796.2004.01380.x

K. Ritchie, Mild cognitive impairment, Dialogues Clin Neurosci, vol.6, pp.333-373, 2004.
DOI : 10.1201/b13196-46
URL : https://hal.archives-ouvertes.fr/inserm-00271473

M. Tierney, J. Szalai, W. Snow, R. Fisher, A. Nores et al., Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study, Neurology, vol.46, issue.3, pp.661-666, 1996.
DOI : 10.1212/WNL.46.3.661

K. Ritchie, S. Artero, and J. Touchon, Classification criteria for mild cognitive impairment: A population-based validation study, Neurology, vol.56, issue.1, pp.37-42, 2001.
DOI : 10.1212/WNL.56.1.37

J. Fisk, H. Merry, and K. Rockwood, Variations in case definition affect prevalence but not outcomes of mild cognitive impairment, Neurology, vol.61, issue.9, pp.1179-84, 2003.
DOI : 10.1212/01.WNL.0000089238.07771.C7

R. Sperling, D. Greve, A. Dale, R. Killiany, J. Holmes et al., Functional MRI detection of pharmacologically induced memory impairment, Proceedings of the National Academy of Sciences, vol.290, issue.5500, pp.455-60, 2002.
DOI : 10.1126/science.290.5500.2315

C. Flicker, M. Serby, and S. Ferris, Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed, Psychopharmacology, vol.10, issue.2, pp.243-50, 1990.
DOI : 10.1007/BF02244414

C. Flicker, S. Ferris, and M. Serby, Hypersensitivity to scopolamine in the elderly, Psychopharmacology, vol.11, issue.2-3, pp.437-478, 1992.
DOI : 10.1007/BF02245172

D. Drachman, D. Noffsinger, B. Sahakian, S. Kurdziel, and P. Fleming, Aging, memory, and the cholinergic system: A study of dichotic listening???, Neurobiology of Aging, vol.1, issue.1, pp.39-43, 1980.
DOI : 10.1016/0197-4580(80)90022-6

M. Feinberg, The Problems of Anticholinergic Adverse Effects in Older Patients, Drugs & Aging, vol.3, issue.4, pp.335-383, 1993.
DOI : 10.2165/00002512-199303040-00004

D. Blazer, C. Federspiel, W. Ray, and W. Schaffner, The Risk of Anticholinergic Toxicity in the Elderly: a Study of Prescribing Practices in Two Populations, Journal of Gerontology, vol.38, issue.1, pp.31-36, 1983.
DOI : 10.1093/geronj/38.1.31

B. Mulsant, B. Pollock, M. Kirshner, C. Shen, H. Dodge et al., Serum Anticholinergic Activity in a Community-Based Sample of Older Adults, Archives of General Psychiatry, vol.60, issue.2, pp.198-203, 2003.
DOI : 10.1001/archpsyc.60.2.198

A. Remillard, A pharmacoepidemiological evaluation of anticholinergic prescribing patterns in the elderly, Pharmacoepidemiology and Drug Safety, vol.5, issue.3, pp.155-64, 1996.
DOI : 10.1002/(SICI)1099-1557(199605)5:3<155::AID-PDS196>3.0.CO;2-D

J. Mintzer and A. Burns, Anticholinergic side-effects of drugs in elderly people, J R Soc Med, vol.93, pp.457-62, 2000.

K. Ritchie, B. Ledesert, and J. Touchon, The eugeria study of cognitive ageing: Who are the ???normal??? elderly?, International Journal of Geriatric Psychiatry, vol.46, issue.12, pp.969-77, 1993.
DOI : 10.1002/gps.930081203

G. Tollefson, J. Montague-clouse, and S. Lancaster, The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population, J Neuropsychiatry Clin Neurosci, vol.3, pp.314-323, 1991.

L. Tune, S. Carr, E. Hoag, and T. Cooper, Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium, Am J Psychiatry, vol.149, pp.1393-1397, 1992.

D. Aizenberg, M. Sigler, A. Weizman, and Y. Barak, Anticholinergic Burden and the Risk of Falls Among Elderly Psychiatric Inpatients: A 4-Year Case-Control Study, International Psychogeriatrics, vol.14, issue.3, pp.307-317, 2002.
DOI : 10.1017/S1041610202008505

A. Moore, O. Keeffe, and S. , Drug-Induced Cognitive Impairment in the Elderly, Drugs & Aging, vol.15, issue.1, pp.15-28, 1999.
DOI : 10.2165/00002512-199915010-00002

S. Doniger, T. Hofmann, and J. Yeh, Predicting CNS Permeability of Drug Molecules: Comparison of Neural Network and Support Vector Machine Algorithms, Journal of Computational Biology, vol.9, issue.6, pp.849-64, 2002.
DOI : 10.1089/10665270260518317

W. Sippl, Computational Approaches for the Prediction of Blood-Brain Barrier Permeation, Current Medicinal Chemistry-Central Nervous System Agents, vol.2, issue.3
DOI : 10.2174/1568015023357996

K. Ritchie, M. Allard, F. Huppert, C. Nargeot, B. Pinek et al., Computerized cognitive examination of the elderly (ECO): The development of a neuropsychological examination for clinic and population use, International Journal of Geriatric Psychiatry, vol.34, issue.11, pp.899-914, 1993.
DOI : 10.1002/gps.930081104

E. Pekkonen, I. Jaaskelainen, S. Kaakkola, and J. Ahveninen, Cholinergic modulation of preattentive auditory processing in aging, NeuroImage, vol.27, issue.2, pp.387-92, 2005.
DOI : 10.1016/j.neuroimage.2005.04.018

S. Tervo, M. Kivipelto, T. Hanninen, M. Vanhanen, M. Hallikainen et al., Incidence and Risk Factors for Mild Cognitive Impairment: A Population-Based Three-Year Follow-Up Study of Cognitively Healthy Elderly Subjects, Dementia and Geriatric Cognitive Disorders, vol.17, issue.3, pp.196-203, 2004.
DOI : 10.1159/000076356