M. J. Arboleda, J. F. Lyons, F. F. Kabbinavar, M. R. Bray, B. E. Snow et al., Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells, Cancer Res, vol.63, pp.196-206, 2003.

C. R. Beals, C. M. Sheridan, C. W. Turck, P. Gardner, and G. R. Crabtree, Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3, Science, vol.275, issue.5308, 1930.
DOI : 10.1126/science.275.5308.1930

A. Bellacosa, J. R. Testa, S. P. Staal, and P. N. Tsichlis, A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region, Science, vol.254, issue.5029, pp.274-277, 1991.
DOI : 10.1126/science.1833819

M. R. Campanero and E. K. Flemington, Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein, Proc. Natl. Acad. Sci. USA 94, pp.2221-2226, 1997.
DOI : 10.1101/gad.10.23.2949

L. C. Cantley, The Phosphoinositide 3-Kinase Pathway, Science, vol.296, issue.5573, pp.1655-1657, 2002.
DOI : 10.1126/science.296.5573.1655

L. C. Cantley, N. , and B. G. , New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway, Proc. Natl. Acad. Sci. USA 96, pp.4240-4245, 1999.
DOI : 10.1146/annurev.biochem.67.1.481

M. Chen, O. Connor, and K. L. , Integrin ??6??4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells, Oncogene, vol.163, issue.32, pp.5125-5130, 2005.
DOI : 10.1038/sj.onc.1208729

C. W. Chow, M. Rincon, J. Cavanagh, M. Dickens, D. et al., Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway, Science, vol.278, issue.5343, pp.1638-1641, 1997.
DOI : 10.1126/science.278.5343.1638

G. R. Crabtree and E. N. Olson, NFAT Signaling, Cell, vol.109, issue.2, pp.67-79, 2002.
DOI : 10.1016/S0092-8674(02)00699-2
URL : http://doi.org/10.1016/s0092-8674(02)00699-2

D. A. Cross, D. R. Alessi, P. Cohen, M. Andjelkovich, and B. A. Hemmings, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, vol.270, issue.6559, pp.785-789, 1995.
DOI : 10.1038/378785a0

F. Czauderna, M. Fechtner, H. Aygun, W. Arnold, A. Klippel et al., Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA, Nucleic Acids Research, vol.31, issue.2, pp.670-682, 2003.
DOI : 10.1093/nar/gkg141

. Akt, PKB regulates actin organization and cell motility via Girdin, APE. Dev. Cell, vol.9, pp.389-402

J. Feng, R. Tamaskovic, Z. Yang, D. P. Brazil, A. Merlo et al., Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation, Journal of Biological Chemistry, vol.279, issue.34, pp.35510-35517, 2004.
DOI : 10.1074/jbc.M404936200

L. Flanagan, K. Van-weelden, C. Ammerman, S. P. Ethier, W. et al., SUM-159PT cells: a novel estrogen independent human breast cancer model system, Breast Cancer Research and Treatment, vol.51, issue.14, pp.193-204, 1999.
DOI : 10.1023/A:1006331716981

P. Friedl and K. Wolf, Tumour-cell invasion and migration: diversity and escape mechanisms, Nature Reviews Cancer, vol.3, issue.5, pp.362-374, 2003.
DOI : 10.1038/nrc1075

T. Gao, F. Furnari, and A. C. Newton, PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth, Molecular Cell, vol.18, issue.1, pp.13-24, 2005.
DOI : 10.1016/j.molcel.2005.03.008

H. Huang, K. M. Regan, F. Wang, D. Wang, D. I. Smith et al., Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation, Proc. Natl, 2005.
DOI : 10.1016/S0092-8674(00)81239-8

J. Hutchinson, J. Jin, R. D. Cardiff, J. R. Woodgett, and W. J. Muller, Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression, Molecular and Cellular Biology, vol.21, issue.6, pp.2203-2212, 2001.
DOI : 10.1128/MCB.21.6.2203-2212.2001

J. N. Hutchinson, J. Jin, R. D. Cardiff, J. R. Woodgett, and W. J. Muller, Activation of Akt-1 (PKB-??) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion, Cancer Research, vol.64, issue.9, pp.3171-3178, 2004.
DOI : 10.1158/0008-5472.CAN-03-3465

S. H. Im and A. Rao, Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling, Mol. Cells, vol.18, pp.1-9, 2004.

T. Jascur, J. Gilman, and T. Mustelin, Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells, Journal of Biological Chemistry, vol.272, issue.22, pp.14483-14488, 1997.
DOI : 10.1074/jbc.272.22.14483

S. Jauliac, C. Lopez-rodriguez, L. M. Shaw, L. F. Brown, A. Rao et al., The role of NFAT transcription factors in integrin-mediated carcinoma invasion, Nature Cell Biology, vol.4, issue.7, pp.540-544, 2002.
DOI : 10.1038/ncb816
URL : https://hal.archives-ouvertes.fr/inserm-00000023

M. D. Kaeser, S. Pebernard, and R. D. Iggo, Regulation of p53 Stability and Function in HCT116 Colon Cancer Cells, Journal of Biological Chemistry, vol.279, issue.9, pp.7598-7605, 2004.
DOI : 10.1074/jbc.M311732200

D. Kim, S. Kim, H. Koh, S. O. Yoon, A. S. Chung et al., Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production, The FASEB Journal, vol.15, issue.11, pp.1953-1962, 2001.
DOI : 10.1096/fj.01-0198com

S. Kurki, K. Peltonen, L. Latonen, T. M. Kiviharju, P. M. Ojala et al., Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation, Cancer Cell, vol.5, issue.5, pp.465-475, 2004.
DOI : 10.1016/S1535-6108(04)00110-2

F. Macian, C. Garcia-rodriguez, and A. Rao, Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun, The EMBO Journal, vol.19, issue.17, pp.4783-4795, 2000.
DOI : 10.1093/emboj/19.17.4783

L. D. Mayo and D. B. Donner, A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus, Proc. Natl. Acad. Sci. USA 98, pp.11598-11603, 2001.
DOI : 10.1073/pnas.93.24.14106

J. P. Northrop, S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman et al., NF-AT components define a family of transcription factors targeted in T-cell activation, Nature, vol.369, issue.6480, pp.497-502, 1994.
DOI : 10.1038/369497a0

H. Okamura, C. Garcia-rodriguez, H. Martinson, J. Qin, D. M. Virshup et al., A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1, Molecular and Cellular Biology, vol.24, issue.10, pp.4184-4195, 2004.
DOI : 10.1128/MCB.24.10.4184-4195.2004

A. K. Patra, S. Y. Na, and U. Bommhardt, Active Protein Kinase B Regulates TCR Responsiveness by Modulating Cytoplasmic-Nuclear Localization of NFAT and NF-??B Proteins, The Journal of Immunology, vol.172, issue.8, pp.4812-4820, 2004.
DOI : 10.4049/jimmunol.172.8.4812

D. R. Plas and C. B. Thompson, Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome, Journal of Biological Chemistry, vol.278, issue.14, pp.12361-12366, 2003.
DOI : 10.1074/jbc.M213069200

K. Reif, S. Lucas, and D. Cantrell, A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function, Current Biology, vol.7, issue.5, pp.285-293, 1997.
DOI : 10.1016/S0960-9822(06)00151-5

C. Rommel, S. C. Bodine, B. A. Clarke, R. Rossman, L. Nunez et al., Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways, Nature Cell Biology, vol.3, issue.11, pp.1009-1013, 2001.
DOI : 10.1038/ncb1101-1009

O. Stal, G. Perez-tenorio, L. Akerberg, B. Olsson, B. Nordenskjold et al., Akt kinases in breast cancer and the results of adjuvant therapy, Breast Cancer Research, vol.274, issue.2, pp.37-44, 2003.
DOI : 10.1074/jbc.274.45.32274

S. Tanno, Y. Mitsuuchi, D. A. Altomare, G. H. Xiao, and T. , AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells, J.R. Cancer Res, vol.61, pp.589-593, 2001.

I. Vivanco and C. L. Sawyers, The phosphatidylinositol 3-Kinase???AKT pathway in human cancer, Nature Reviews Cancer, vol.2, issue.7, pp.489-501, 2002.
DOI : 10.1038/nrc839

B. P. Zhou, Y. Liao, W. Xia, Y. Zou, B. Spohn et al., HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation, Nature Cell Biology, vol.3, issue.11, pp.973-982, 2001.
DOI : 10.1038/ncb1101-973