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Article Dans Une Revue International Journal of Cancer Année : 2023

Pain in desmoid-type fibromatosis: Prevalence, determinants and prognosis value

Jean Yves Blay

Résumé

The aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid-type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), managed by surgery, active surveillance or systemic treatments, with pain assessment at diagnosis. Patients were invited to fill QLQ-C30 questionnaire and Hospital Anxiety Depression Scale. Determinants were identified using logistic models. Prognostic value on event-free survival (EFS) was evaluated using the Cox model. Overall, 382 patients were included in the current study (median age: 40.2 years; 117 men). The prevalence of pain was 36%, without significant difference according to first-line treatment (P =.18). In the multivariate analysis, pain was significantly associated with tumor size >50 mm (P =.013) and tumor site (P <.001); pain was more frequent in the neck and shoulder locations (odds ratio: 3.05 [1.27-7.29]). Pain at baseline was significantly associated with poor quality of life (P <.001), depression (P =.02), lower performance status (P =.03) and functional impairment (P =.001); we also observed a nonsignificant association with anxiety (P =.10). In the univariate analysis, baseline pain was associated with poor EFS; the 3-year EFS was 54% in patients with pain compared to 72% in those without pain. After adjustment for sex, age, size and line of treatment, pain was still associated with poor EFS (hazard ratio: 1.82 [1.23-2.68], P =.003). One third of recently diagnosed patients with DF experienced pain, especially those with larger tumors and neck/shoulder locations. Pain was associated with unfavorable EFS after adjustment for the confounders.

Domaines

Cancer
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Dates et versions

hal-04106296 , version 1 (06-06-2023)

Identifiants

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Nicolas Penel, Sylvie Bonvalot, Marie Cécile Le Deley, Antoine Italiano, Camille Tlemsani, et al.. Pain in desmoid-type fibromatosis: Prevalence, determinants and prognosis value. International Journal of Cancer, 2023, 153 (2), pp.407-416. ⟨10.1002/ijc.34493⟩. ⟨hal-04106296⟩
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