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Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France

Teresa Rojas Rojas 1 Isabelle Poizot-Martin 1, 2, 3 David Rey 4 Claudine Duvivier 5, 6, 7, 8, 9 Firouzé Bani-Sadr 10 André Cabie 11, 12 Pierre Delobel 13, 14 Christine Jacomet 15 Clotilde Allavena 16, 17 Tristan Ferry 18, 19 Pascal Pugliese 20, 21 Marc-Antoine Valantin 22, 23 Isabelle Lamaury 24 Laurent Hustache-Matthieu 25 Anne Fresard 26 Tamazighth Houyou 2, 3, 27 Thomas Huleux 28 Antoine Cheret 29, 30 Alain Makinson 31, 32 Véronique Obry-Roguet 1 Caroline Lions 1 Maria Patrizia Carrieri 2, 3, 27 Camelia Protopopescu 2, 3, 27 
Abstract : Background We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program. Setting: This is a retrospective study based on the longitudinal data of the French Dat’AIDS cohort. Methods: Standardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection. Results: The 2010–2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6–33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18–3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm3 (SIR = 2.62, 95% CI: 1.45–4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93–13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47–8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07–3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42–0.73). Conclusion: The present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk.
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Submitted on : Friday, July 1, 2022 - 4:05:32 PM
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Teresa Rojas Rojas, Isabelle Poizot-Martin, David Rey, Claudine Duvivier, Firouzé Bani-Sadr, et al.. Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France. PLoS ONE, Public Library of Science, 2022, 17 (3), pp.e0261069. ⟨10.1371/journal.pone.0261069⟩. ⟨hal-03711743⟩

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