Skip to Main content Skip to Navigation
Journal articles

Encapsulation of Hydrophobic Porphyrins into Biocompatible Nanoparticles: An Easy Way to Benefit of Their Two-Photon Phototherapeutic Effect without Hydrophilic Functionalization

Abstract : Star-shaped hydrophobic porphyrins, acting as powerful fluorescent two-photon photosensitizers for oxygen in organic solvents, can easily be loaded into PMLABe polymeric nanoparticles at various concentrations. In this contribution, the performance of these porphyrin-containing nanoparticles in terms of photodynamic therapy (PDT) is compared to those of the corresponding water-soluble porphyrin analogues when irradiated in MCF-7 cancer cells. While quite promising results are obtained for performing PDT with these nanoparticles, validating this approach as a mean for using more easily accessible and less expensive photosensitizers, from a synthetic perspective, we also show that their luminescence can still be used for bioimaging purposes in spite of their confinement in the nanoparticles, validating also the use of these nano-objects for theranostic purposes.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03687345
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Thursday, September 22, 2022 - 1:55:30 PM
Last modification on : Tuesday, September 27, 2022 - 4:34:08 AM

File

cancers-14-02358.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Limiao Shi, Christophe Nguyen, Morgane Daurat, Nicolas Richy, Corentin Gauthier, et al.. Encapsulation of Hydrophobic Porphyrins into Biocompatible Nanoparticles: An Easy Way to Benefit of Their Two-Photon Phototherapeutic Effect without Hydrophilic Functionalization. Cancers, MDPI, 2022, 14 (10), pp.2358. ⟨10.3390/cancers14102358⟩. ⟨hal-03687345⟩

Share

Metrics

Record views

0

Files downloads

0