Skip to Main content Skip to Navigation
Journal articles

Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective

Abstract : Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by acting as both a carbon and electron carrier and a signaling molecule between cells and tissues. In recent years, increasing evidence report its key role in white, beige, and brown adipose tissue biology, and highlights new mechanisms by which lactate participates in the maintenance of whole-body energy homeostasis. Lactate displays a wide range of biological effects in adipose cells not only through its binding to the membrane receptor but also through its transport and the subsequent effect on intracellular metabolism notably on redox balance. This study explores how lactate regulates adipocyte metabolism and plasticity by balancing intracellular redox state and by regulating specific signaling pathways. We also emphasized the contribution of adipose tissues to the regulation of systemic lactate metabolism, their roles in redox homeostasis, and related putative physiopathological repercussions associated with their decline in metabolic diseases and aging.
Complete list of metadata
Contributor : Audrey Carrière-Pazat Connect in order to contact the contributor
Submitted on : Wednesday, October 13, 2021 - 1:07:31 PM
Last modification on : Tuesday, October 19, 2021 - 11:18:16 PM


Lagarde et al. Frontiers in Ph...
Publication funded by an institution



Damien Lagarde, Yannick Jeanson, Jean-Charles Portais, Anne Galinier, Isabelle Ader, et al.. Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective. Frontiers in Physiology, Frontiers, 2021, 12, pp.689747. ⟨10.3389/fphys.2021.689747⟩. ⟨hal-03376213⟩



Record views


Files downloads