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X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom

Abstract : Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with conventional (broad beam) irradiations. In addition, the clinical translation of the minibeam treatment at a conventional irradiator is evaluated through a possible human head treatment plan
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https://hal.archives-ouvertes.fr/hal-03366784
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Submitted on : Wednesday, October 13, 2021 - 12:38:42 PM
Last modification on : Monday, November 22, 2021 - 2:18:07 PM

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Marios Sotiropoulos, Elise Brisebard, Marine Le Dudal, Gregory Jouvion, Marjorie Juchaux, et al.. X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom. Clinical and Translational Radiation Oncology, Elsevier, 2021, 27, pp.44-49. ⟨10.1016/j.ctro.2021.01.001⟩. ⟨hal-03366784⟩

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