Long-lasting severe immune dysfunction in Ebola virus disease survivors - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

Long-lasting severe immune dysfunction in Ebola virus disease survivors

(1) , (1) , (1) , (1) , (2, 3, 1, 4) , (4) , (4) , (5, 6) , (5) , (7) , (1) , (5, 6, 8) , (9) , (10) , (7) , (5, 7, 11) , (8) , (12, 4, 2) , (1) , (1)
1
2
3
4
5
6
7
8
9
10
11
12
Aurélie Wiedemann
Cécile Lefebvre
Mélany Durand
  • Function : Author
Miriam Krüger
  • Function : Author
Slim Fourati
  • Function : Author
Christine Lacabaratz
Yves Lévy
  • Function : Correspondent author
  • PersonId : 993190

Connectez-vous pour contacter l'auteur

Abstract

Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in 'inflammation' and 'antiviral' pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of "chronic Ebola virus disease (CEVD)".
Fichier principal
Vignette du fichier
s41467-020-17489-7.pdf (1.25 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

hal-03160838 , version 2 (29-09-2020)
hal-03160838 , version 1 (05-03-2021)

Identifiers

Cite

Aurélie Wiedemann, Emile Foucat, Hakim Hocini, Cécile Lefebvre, Boris Hejblum, et al.. Long-lasting severe immune dysfunction in Ebola virus disease survivors. Nature Communications, 2020, 11 (1), pp.3730. ⟨10.1038/s41467-020-17489-7⟩. ⟨hal-03160838v2⟩
164 View
185 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More