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Article Dans Une Revue International Journal of Molecular Sciences Année : 2020

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

Résumé

Deimination, also known as citrullination, corresponds to the conversion of the amino acid arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post-translational modification is catalyzed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). Deimination is implicated in a growing number of physiological processes (innate and adaptive immunity, gene regulation, embryonic development, etc.) and concerns several human diseases (rheumatoid arthritis, neurodegenerative diseases, female infertility, cancer, etc.). Here, we update the involvement of PADs in both the homeostasis of skin and skin diseases. We particularly focus on keratinocyte differentiation and the epidermal barrier function, and on hair follicles. Indeed, alteration of PAD activity in the hair shaft is responsible for two hair disorders, the uncombable hair syndrome and a particular form of inflammatory scarring alopecia, mainly affecting women of African ancestry.
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Dates et versions

hal-03153570 , version 1 (26-02-2021)

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Marie-Claire Mechin, Hidenari Takahara, Michel Simon. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases. International Journal of Molecular Sciences, 2020, 21 (2), pp.566. ⟨10.3390/ijms21020566⟩. ⟨hal-03153570⟩
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