Skip to Main content Skip to Navigation
New interface
Journal articles

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Abstract : Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique biological features and response profiles to external and internal stimuli. However, there is no coherent picture about how this diversity of cell states is transcriptionally generated. Here, we use deep single cell analysis to resolve fate splits and molecular biasing processes during sensory neurogenesis in mice. Our results identify a complex series of successive and specific transcriptional changes in post-mitotic neurons that delineate hierarchical regulatory states leading to the generation of the main sensory neuron classes. In addition, our analysis identifies previously undetected early gene modules expressed long before fate determination although being clearly associated with defined sensory subtypes. Overall, the early diversity of sensory neurons is generated through successive bi-potential intermediates in which synchronization of relevant gene modules and concurrent repression of competing fate programs precede cell fate stabilization and final commitment.
Complete list of metadata

Cited literature [52 references]  Display  Hide  Download
Contributor : Myriam Bodescot Connect in order to contact the contributor
Submitted on : Friday, September 25, 2020 - 4:00:49 PM
Last modification on : Wednesday, November 3, 2021 - 9:56:28 AM
Long-term archiving on: : Thursday, December 3, 2020 - 6:07:51 PM


Publication funded by an institution




Louis Faure, Yiqiao Wang, Maria Eleni Kastriti, Paula Fontanet, Kylie K y Cheung, et al.. Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nature Communications, 2020, 11 (1), pp.4175. ⟨10.1038/s41467-020-17929-4⟩. ⟨inserm-02949466⟩



Record views


Files downloads