C. Bousquet-antonelli and J. M. Deragon, A comprehensive analysis of the La-motif protein superfamily, RNA, vol.15, pp.750-764, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00698535

R. J. Maraia and R. V. Intine, Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function, Mol. Cell. Biol, vol.21, pp.367-379, 2001.

M. A. Bayfield, R. Yang, and R. J. Maraia, Conserved and divergent features of the structure and function of La and La-related proteins (LARPs), Biochim. Biophys. Acta, vol.1799, pp.365-378, 2010.

C. Maris, C. Dominguez, and F. H. Allain, The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression, FEBS J, vol.272, pp.2118-2131, 2005.

C. Alfano, D. Sanfelice, J. Babon, G. Kelly, A. Jacks et al., Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein, Nat. Struct. Mol. Biol, vol.11, pp.323-329, 2004.

O. Kotik-kogan, E. R. Valentine, D. Sanfelice, M. R. Conte, and S. Curry, Structural analysis reveals conformational plasticity in the recognition of RNA 3 ends by the human La protein, Structure, vol.16, pp.852-862, 2008.

L. Martino, S. Pennell, G. Kelly, B. Busi, P. Brown et al., Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module, Nucleic Acids Res, vol.43, pp.645-660, 2015.

R. J. Maraia and M. A. Bayfield, The La protein-RNA complex surfaces, Mol. Cell, vol.21, pp.149-152, 2006.

B. J. Krueger, C. Jeronimo, B. B. Roy, A. Bouchard, C. Barrandon et al., LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated, Nucleic Acids Res, vol.36, pp.2219-2229, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00333193

C. Jeronimo, D. Forget, A. Bouchard, Q. Li, G. Chua et al., Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme, Mol. Cell, vol.27, pp.262-274, 2007.

N. He, N. S. Jahchan, E. Hong, Q. Li, M. A. Bayfield et al., A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis, Mol. Cell, vol.29, pp.588-599, 2008.

A. R. Gruber, C. Kilgus, A. Mosig, I. L. Hofacker, W. Hennig et al., Arthropod 7SK RNA, Mol. Biol. Evol, vol.25, pp.1923-1930, 2008.

D. Nguyen, B. J. Krueger, S. C. Sedore, J. E. Brogie, J. T. Rogers et al., The Drosophila 7SK snRNP and the essential role of dHEXIM in development, Nucleic Acids Res, vol.40, pp.5283-5297, 2012.

K. L. Witkin and K. Collins, Holoenzyme proteins required for the physiological assembly and activity of telomerase, Genes Dev, vol.18, pp.1107-1118, 2004.

G. Diribarne and O. Bensaude, 7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor, RNA Biol, vol.6, pp.122-128, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00406242

B. M. Peterlin, J. E. Brogie, and D. H. Price, 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription, Wiley Interdiscip. Rev. RNA, vol.3, pp.92-103, 2012.

N. F. Marshall and D. H. Price, Purification of P-TEFb, a transcription factor required for the transition into productive elongation, J. Biol. Chem, vol.270, pp.12335-12338, 1995.

B. M. Peterlin and D. H. Price, Controlling the elongation phase of transcription with P-TEFb, Mol. Cell, vol.23, pp.297-305, 2006.

J. Guo and D. H. Price, RNA polymerase II transcription elongation control, Chem. Rev, vol.113, pp.8583-8603, 2013.

C. G. Danko, N. Hah, X. Luo, A. L. Martins, L. Core et al., Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells, Mol. Cell, vol.50, pp.212-222, 2013.

A. Saunders, L. J. Core, C. Sutcliffe, J. T. Lis, and H. L. Ashe, Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription, Genes Dev, vol.27, pp.1146-1158, 2013.

Z. Yang, Q. Zhu, K. Luo, and Q. Zhou, The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription, Nature, vol.414, pp.317-322, 2001.

V. T. Nguyen, T. Kiss, A. A. Michels, and O. Bensaude, 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes, Nature, vol.414, pp.322-325, 2001.

A. A. Michels, V. T. Nguyen, A. Fraldi, V. Labas, M. Edwards et al., MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner, Mol.Cell. Biol, vol.23, pp.4859-4869, 2003.

A. A. Michels, A. Fraldi, Q. Li, T. E. Adamson, F. Bonnet et al., Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor, EMBO J, vol.23, pp.2608-2619, 2004.

M. Barboric, J. Kohoutek, J. P. Price, D. Blazek, D. H. Price et al., Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb, EMBO J, vol.24, pp.4291-4303, 2005.

Q. Li, J. J. Cooper, G. H. Altwerger, M. D. Feldkamp, M. A. Shea et al., HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells, Nucleic Acids Res, vol.35, pp.2503-2512, 2007.

A. Markert, M. Grimm, J. Martinez, J. Wiesner, A. Meyerhans et al., The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes, EMBO Rep, vol.9, pp.569-575, 2008.

Y. Xue, Z. Yang, R. Chen, and Q. Zhou, A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP, Nucleic Acids Res, vol.38, pp.360-369, 2010.

D. A. Wassarman and J. A. Steitz, Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function, Mol. Cell. Biol, vol.11, pp.3432-3445, 1991.

S. Egloff, E. Van-herreweghe, and T. Kiss, Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding, Mol.Cell. Biol, vol.26, pp.630-642, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00021148

L. Muniz, S. Egloff, and T. Kiss, RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Nucleic Acids Res, vol.41, pp.4686-4698, 2013.

E. Van-herreweghe, S. Egloff, I. Goiffon, B. E. Jady, C. Froment et al., Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb, EMBO J, vol.26, pp.3570-3580, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00309025

F. Belanger, H. Baigude, and T. M. Rana, U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex, J. Mol. Biol, vol.386, pp.1094-1107, 2009.

I. Lebars, D. Martinez-zapien, A. Durand, J. Coutant, B. Kieffer et al., HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements, Nucleic Acids Res, vol.38, pp.7749-7763, 2010.

B. J. Krueger, K. Varzavand, J. J. Cooper, and D. H. Price, The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK, PloS one, vol.5, p.12335, 2010.

M. Marz, A. Donath, N. Verstraete, V. T. Nguyen, P. F. Stadler et al., Evolution of 7SK RNA and its protein partners in metazoa, Mol. Biol. Evol, vol.26, pp.2821-2830, 2009.

Y. Cheng, Z. Jin, R. Agarwal, K. Ma, J. Yang et al., LARP7 is a potential tumor suppressor gene in gastric cancer, Lab. Invest, vol.92, pp.1013-1019, 2012.

H. Najmabadi, H. Hu, M. Garshasbi, T. Zemojtel, S. S. Abedini et al., Deep sequencing reveals 50 novel genes for recessive cognitive disorders, Nature, vol.478, pp.57-63, 2011.

A. M. Alazami, M. Al-owain, F. Alzahrani, T. Shuaib, H. Al-shamrani et al., Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism, Hum. Mutat, vol.33, pp.1429-1434, 2012.

T. G. Battye, L. Kontogiannis, O. Johnson, H. R. Powell, and A. G. Leslie, iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM, Acta Crystallogr. D Biol. Crystallogr, vol.67, pp.271-281, 2011.

P. Evans, Scaling and assessment of data quality, Acta Crystallogr. D Biol. Crystallogr, vol.62, pp.72-82, 2006.

M. D. Winn, C. C. Ballard, K. D. Cowtan, E. J. Dodson, P. Emsley et al., Overview of the CCP4 suite and current developments, Acta Crystallogr. D Biol. Crystallogr, vol.67, pp.235-242, 2011.

A. J. Mccoy, Solving structures of protein complexes by molecular replacement with Phaser, Acta Crystallogr. D Biol. Crystallogr, vol.63, pp.32-41, 2007.

A. J. Mccoy, R. W. Grosse-kunstleve, P. D. Adams, M. D. Winn, L. C. Storoni et al., Phaser crystallographic software, J. Appl. Crystallogr, vol.40, pp.658-674, 2007.

A. T. Brunger, Version 1.2 of the crystallography and NMR system, Nat. Protoc, vol.2, pp.2728-2733, 2007.

A. T. Brunger, P. D. Adams, G. M. Clore, W. L. Delano, P. Gros et al., Crystallography & NMR system: a new software suite for macromolecular structure determination, Acta Crystallogr. D. Biol. Crystallogr, vol.54, pp.905-921, 1998.

P. Emsley and K. Cowtan, Coot: model-building tools for molecular graphics, Acta Crystallogr. D Biol. Crystallogr, vol.60, pp.2126-2132, 2004.

R. C. Edgar, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Res, vol.32, pp.1792-1797, 2004.

M. Singh, Z. Wang, B. K. Koo, A. Patel, D. Cascio et al., Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65, Mol. Cell, vol.47, pp.16-26, 2012.

P. Gouet, E. Courcelle, D. I. Stuart, and F. Metoz, ESPript: analysis of multiple sequence alignments in PostScript, Bioinformatics, vol.15, pp.305-308, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00314288

M. Parisien and F. Major, The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data, Nature, vol.452, pp.51-55, 2008.

M. A. Durney and V. M. Souza, Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR, J. Mol. Biol, vol.404, pp.555-567, 2010.

M. Singh, C. P. Choi, and J. Feigon, xRRM: a new class of RRM found in the telomerase La family protein p65, RNA Biol, vol.10, pp.353-359, 2013.

D. I. Svergun, M. V. Petoukhov, and M. H. Koch, Determination of domain structure of proteins from X-ray solution scattering, Biophys. J, vol.80, pp.2946-2953, 2001.

M. V. Petoukhov and D. I. Svergun, Global rigid body modeling of macromolecular complexes against small-angle scattering data, Biophys. J, vol.89, pp.1237-1250, 2005.

U. B. Ericsson, B. M. Hallberg, G. T. Detitta, N. Dekker, and P. Nordlund, Thermofluor-based high-throughput stability optimization of proteins for structural studies, Anal. Biochem, vol.357, pp.289-298, 2006.

G. Dong, G. Chakshusmathi, S. L. Wolin, and K. M. Reinisch, Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch, EMBO J, vol.23, pp.1000-1007, 2004.

M. Teplova, Y. R. Yuan, A. T. Phan, L. Malinina, S. Ilin et al., Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen, Mol. Cell, vol.21, pp.75-85, 2006.

C. C. Query, R. C. Bentley, and J. D. Keene, A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein, Cell, vol.57, pp.89-101, 1989.

M. Heinig and D. Frishman, STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins, Nucleic Acids Res, vol.32, pp.500-502, 2004.

G. M. Daubner, A. Clery, and F. H. Allain, RRM-RNA recognition: NMR or crystallography. . . and new findings, Curr. Opin. Struct. Biol, vol.23, pp.100-108, 2013.

K. M. Sinha, J. Gu, Y. Chen, and R. Reddy, Adenylation of small RNAs in human cells. Development of a cell-free system for accurate adenylation on the 3 -end of human signal recognition particle RNA, J. Biol. Chem, vol.273, pp.6853-6859, 1998.

S. C. Walker, J. M. Avis, and G. L. Conn, General plasmids for producing RNA in vitro transcripts with homogeneous ends, Nucleic Acids Res, vol.31, p.82, 2003.

N. He, N. S. Jahchan, E. Hong, Q. Li, M. A. Bayfield et al., A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis, Mol. Cell, vol.29, pp.588-599, 2008.

C. Ehresmann, F. Baudin, M. Mougel, P. Romby, J. P. Ebel et al., Probing the structure of RNAs in solution, Nucleic Acids Res, vol.15, pp.9109-9128, 1987.

M. Zuker, Mfold web server for nucleic acid folding and hybridization prediction, Nucleic Acids Res, vol.31, pp.3406-3415, 2003.

R. Yang, S. A. Gaidamakov, J. Xie, J. Lee, L. Martino et al., , 2011.

, interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability, La-related protein 4 binds poly(A), vol.31, pp.542-556

K. Fujinaga, Z. Luo, and B. M. Peterlin, Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells, J. Biol. Chem, vol.289, pp.21181-21190, 2014.

T. H. Tahirov, N. D. Babayeva, K. Varzavand, J. J. Cooper, S. C. Sedore et al., Crystal structure of HIV-1 Tat complexed with human P-TEFb, Nature, vol.465, pp.747-751, 2010.

Q. Li, J. J. Cooper, G. H. Altwerger, M. D. Feldkamp, M. A. Shea et al., HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells, Nucleic Acids Res, vol.35, pp.2503-2512, 2007.