Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH), J. Toxicol. Environ. Health. B. Crit. Rev, vol.17, pp.63-94, 2014. ,
Migration of plasticizers from PVC medical devices: Development of an infusion model, Int. J. Pharm, vol.494, pp.136-145, 2015. ,
Analysis of PVC plasticizers in medical devices and infused solutions by GC-MS, J. Pharm. Biomed Anal, vol.118, pp.206-213, 2016. ,
Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism, Sci. Rep, vol.7, issue.1, p.11072, 2017. ,
Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), Environ. Int, vol.102, pp.79-86, 2017. ,
Toxicity of Hexamoll(®) DINCH(®) following intravenous administration, Toxicol Lett, vol.238, pp.100-109, 2015. ,
Simultaneous determination of polyvinylchloride plasticizers di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate and its degradation products in blood by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A, vol.1410, pp.173-180, 2015. ,
Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine, Chemosphere, vol.145, pp.10-16, 2016. ,
In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line, Chemosphere, vol.173, pp.452-459, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01856278
Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ER?, ER?, and AR, Toxicol. Lett, vol.277, pp.54-63, 2017. ,
The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ER?, ER?, AR, PPAR? and PPAR?, Toxicol. Lett, vol.287, pp.83-91, 2018. ,
Please note: DINP is restricted according Annex XVII of Regulation (EC) No 1907/2006 and can therefore not be used for toys which can be put into the mouth by children, 1907. ,
A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months, Environ Health Perspect, vol.122, pp.998-1005, 2014. ,
Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3), Int. J. Hyg. Environ. Health, vol.219, pp.33-39, 2016. ,
evaluation of exposure to phthalate esters and DINCH in urine and nails from a Norwegian study population, Environ. Res, vol.151, pp.80-90, 2016. ,
Multi-pathway human exposure assessment of phthalate esters and DINCH, Environ. Int, vol.112, pp.115-126, 2018. ,
Phthalates and human health, Occup. Environ. Med, vol.62, pp.806-818, 2005. ,
Urinary metabolites of di(2-ethylhexyl) phthalate relation to sperm motility, reactive oxygen species generation, and apoptosis in polyvinyl chloride workers, Int. Arch. Occup. Environ. Health, vol.87, pp.635-646, 2014. ,
Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients, Environ Int, vol.81, pp.64-72, 2015. ,
Migration of DEHP and DINP into dust from PVC flooring products at different surface temperature, Sci. Total Environ, vol.15, pp.441-446 ,
Exposure assessment issues in epidemiology studies of phthalates, Environ. Int, vol.85, pp.27-39, 2015. ,
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells, Int. J. Cancer, vol.86, pp.399-407, 2000. ,
Determination of secondary, oxidised di-isononylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers, J. Chromatogr. B Analyt. Technol. Biomed Life Sci, vol.847, pp.114-125, 2007. ,
Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP, Int. J. Hyg. Environ. Health, vol.210, pp.9-19, 2007. ,
Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses, Arch. Toxicol, vol.87, pp.799-806, 2013. ,
Phthalate metabolites in 24-h urine samples of the German Environmental Specimen Bank (ESB) from 1988 to 2015 and a comparison with US NHANES data from, 1999. ,
, Int. J. Hyg. Environ. Health, vol.220, issue.2, pp.130-141
In vitro evaluation of the quality of blood products collected and stored in systems completely free of di(2-ethylhexyl)phthalate-plasticized materials, Transfusion, vol.55, pp.522-531, 2015. ,
Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters, Bioorg. Med. Chem, vol.13, pp.3461-3465, 2005. ,
, Regulation (EC) No 1272/2008 of the european parliament and of the council, Official Journal of the European Union, 2008.
, /745 of the European Parliament and of the Council of 5 April 2017 on medical devices, Official Journal of the European Union
Scientific Committee on Emerging and Newly-Identified Health Risks) opinion on the safety of medical devices containing dehp-plasticized pvc or other plasticizers on Neonates and other groups possibly at risk, 2008. ,
, Scientific Committee on Emerging and Newly-Identified Health Risks) opinion on the safety of medical devices containing dehp-plasticized pvc or other plasticizers on Neonates and other groups possibly at risk, 2016.
Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC-MS/MS, J. Chromatogr. B, pp.123-130, 2012. ,
Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 h urine samples from the German Environmental Specimen Bank, Int J Hyg Environ Health, vol.217, pp.421-426, 2014. ,
Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers, Arch. Toxicol, vol.91, pp.179-188, 2017. ,
Quantification of 22 phthalate metabolites in human urine, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci, vol.860, pp.106-112, 2007. ,
Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers, Biomarkers, vol.12, pp.133-144, 2007. ,
Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, Environ. Res, vol.126, pp.159-163, 2000. ,
Increased levels of phthalates in very low birth weight infants with septicemia and bronchopulmonary dysplasia, Environ Int, pp.228-234, 2016. ,
Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study, Int. J. Hyg. Environ. Health, vol.210, pp.319-333, 2007. ,
Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes, Sci. Rep, vol.7, p.40153, 2017. ,
Exposure assessment of phthalates in French pregnant women: results of the ELFE pilot study, Int. J. Hyg. Environ. Health, vol.216, pp.271-279, 2013. ,
URL : https://hal.archives-ouvertes.fr/ineris-00963467
Promotion of breast cancer cells MDA-MB-231 invasion by di(2-ethylhexyl)phthalate through matrix metalloproteinase-2/-9 overexpression, Environ. Sci. Pollut. Res. Int, vol.23, pp.9742-9749, 2016. ,