V. S. Bhat, J. L. Durham, G. L. Ball, and J. C. English, Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH), J. Toxicol. Environ. Health. B. Crit. Rev, vol.17, pp.63-94, 2014.

L. Bernard, R. Cueff, M. Chagnon, F. Abdoulouhab, B. Décaudin et al., Migration of plasticizers from PVC medical devices: Development of an infusion model, Int. J. Pharm, vol.494, pp.136-145, 2015.

D. Bourdeaux, M. Yessaad, P. Chennell, V. Larbre, T. Eljezi et al., Analysis of PVC plasticizers in medical devices and infused solutions by GC-MS, J. Pharm. Biomed Anal, vol.118, pp.206-213, 2016.

E. Campioli, S. Lee, M. Lau, L. Marques, and V. Papadopoulos, Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism, Sci. Rep, vol.7, issue.1, p.11072, 2017.

L. Correia-sá, A. Schütze, S. Norberto, C. Calhau, V. F. Domingues et al., Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), Environ. Int, vol.102, pp.79-86, 2017.

R. M. David, R. D. White, M. J. Larson, J. K. Herman, and R. Otter, Toxicity of Hexamoll(®) DINCH(®) following intravenous administration, Toxicol Lett, vol.238, pp.100-109, 2015.

E. Eckert, J. Müller, and T. Göen, Simultaneous determination of polyvinylchloride plasticizers di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate and its degradation products in blood by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A, vol.1410, pp.173-180, 2015.

E. Eckert, F. Münch, T. Göen, A. Purbojo, J. Müller et al., Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine, Chemosphere, vol.145, pp.10-16, 2016.

T. Eljezi, P. Pinta, D. Richard, J. Pinguet, J. M. Chezal et al., In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line, Chemosphere, vol.173, pp.452-459, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01856278

A. Engel, T. Buhrke, F. Imber, S. Jessel, A. Seidel et al., Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ER?, ER?, and AR, Toxicol. Lett, vol.277, pp.54-63, 2017.

A. Engel, T. Buhrke, S. Kasper, A. C. Behr, A. Braeuning et al., The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ER?, ER?, AR, PPAR? and PPAR?, Toxicol. Lett, vol.287, pp.83-91, 2018.

. Echa, Please note: DINP is restricted according Annex XVII of Regulation (EC) No 1907/2006 and can therefore not be used for toys which can be put into the mouth by children, 1907.

H. Frederiksen, T. Kuiri-hänninen, K. M. Main, L. Dunkel, and U. Sankilampi, A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months, Environ Health Perspect, vol.122, pp.998-1005, 2014.

H. Fromme, A. Schütze, T. Lahrz, M. Kraft, L. Fembacher et al., Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3), Int. J. Hyg. Environ. Health, vol.219, pp.33-39, 2016.

G. Giovanoulis, A. Alves, E. Papadopoulou, A. P. Cousins, A. Schütze et al., evaluation of exposure to phthalate esters and DINCH in urine and nails from a Norwegian study population, Environ. Res, vol.151, pp.80-90, 2016.

G. Giovanoulis, T. Bui, F. Xu, E. Papadopoulou, J. A. Padilla-sanchez et al., Multi-pathway human exposure assessment of phthalate esters and DINCH, Environ. Int, vol.112, pp.115-126, 2018.

R. Hauser and A. M. Calafat, Phthalates and human health, Occup. Environ. Med, vol.62, pp.806-818, 2005.

L. P. Huang, C. C. Lee, J. P. Fan, P. H. Kuo, T. S. Shih et al., Urinary metabolites of di(2-ethylhexyl) phthalate relation to sperm motility, reactive oxygen species generation, and apoptosis in polyvinyl chloride workers, Int. Arch. Occup. Environ. Health, vol.87, pp.635-646, 2014.

J. Huygh, K. Clotman, G. Malarvannan, A. Covaci, T. Schepens et al., Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients, Environ Int, vol.81, pp.64-72, 2015.

S. Jeon, K. T. Kim, and K. Choi, Migration of DEHP and DINP into dust from PVC flooring products at different surface temperature, Sci. Total Environ, vol.15, pp.441-446

L. E. Johns, G. S. Cooper, A. Galizia, and J. D. Meeker, Exposure assessment issues in epidemiology studies of phthalates, Environ. Int, vol.85, pp.27-39, 2015.

J. Kleeff, M. Kornmann, H. Sawhney, and M. Korc, Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells, Int. J. Cancer, vol.86, pp.399-407, 2000.

H. M. Koch, J. Müller, and J. Angerer, Determination of secondary, oxidised di-isononylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers, J. Chromatogr. B Analyt. Technol. Biomed Life Sci, vol.847, pp.114-125, 2007.

H. M. Koch and J. Angerer, Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP, Int. J. Hyg. Environ. Health, vol.210, pp.9-19, 2007.

H. M. Koch, A. Schütze, C. Pälmke, J. Angerer, and T. Brüning, Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses, Arch. Toxicol, vol.87, pp.799-806, 2013.

H. M. Koch, M. Rüther, A. Schütze, A. Conrad, C. Pälmke et al., Phthalate metabolites in 24-h urine samples of the German Environmental Specimen Bank (ESB) from 1988 to 2015 and a comparison with US NHANES data from, 1999.

, Int. J. Hyg. Environ. Health, vol.220, issue.2, pp.130-141

J. W. Lagerberg, E. Gouwerok, R. Vlaar, M. Go, and D. De-korte, In vitro evaluation of the quality of blood products collected and stored in systems completely free of di(2-ethylhexyl)phthalate-plasticized materials, Transfusion, vol.55, pp.522-531, 2015.

F. Nuti, S. Hildenbrand, M. Chelli, R. Wodarz, and A. M. Papini, Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters, Bioorg. Med. Chem, vol.13, pp.3461-3465, 2005.

, Regulation (EC) No 1272/2008 of the european parliament and of the council, Official Journal of the European Union, 2008.

, /745 of the European Parliament and of the Council of 5 April 2017 on medical devices, Official Journal of the European Union

. Scenihr, Scientific Committee on Emerging and Newly-Identified Health Risks) opinion on the safety of medical devices containing dehp-plasticized pvc or other plasticizers on Neonates and other groups possibly at risk, 2008.

, Scientific Committee on Emerging and Newly-Identified Health Risks) opinion on the safety of medical devices containing dehp-plasticized pvc or other plasticizers on Neonates and other groups possibly at risk, 2016.

A. Schütze, C. Pälmke, J. Angerer, T. Weiss, T. Brüning et al., Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC-MS/MS, J. Chromatogr. B, pp.123-130, 2012.

A. Schütze, M. Kolossa-gehring, P. Apel, T. Brüning, and H. M. Koch, Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 h urine samples from the German Environmental Specimen Bank, Int J Hyg Environ Health, vol.217, pp.421-426, 2014.

A. Schütze, R. Otter, H. Modick, A. Langsch, T. Brüning et al., Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers, Arch. Toxicol, vol.91, pp.179-188, 2017.

M. J. Silva, E. Samandar, J. L. Preau, . Jr, J. A. Reidy et al., Quantification of 22 phthalate metabolites in human urine, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci, vol.860, pp.106-112, 2007.

M. J. Silva, J. A. Reidy, K. Kato, J. L. Preau, . Jr et al., Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers, Biomarkers, vol.12, pp.133-144, 2007.

M. J. Silva, T. Jia, E. Samandar, J. L. Preau, and A. M. Calafat, Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, Environ. Res, vol.126, pp.159-163, 2000.

K. Strømmen, J. L. Lyche, E. W. Blakstad, S. J. Moltu, M. B. Veierød et al., Increased levels of phthalates in very low birth weight infants with septicemia and bronchopulmonary dysplasia, Environ Int, pp.228-234, 2016.

M. Wittassek, G. A. Wiesmüller, H. M. Koch, R. Eckard, L. Dobler et al., Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study, Int. J. Hyg. Environ. Health, vol.210, pp.319-333, 2007.

H. Ye, M. Ha, M. Yang, P. Yue, Z. Xie et al., Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes, Sci. Rep, vol.7, p.40153, 2017.

F. A. Zeman, C. Boudet, K. Tack, A. Floch-barneaud, C. Brochot et al., Exposure assessment of phthalates in French pregnant women: results of the ELFE pilot study, Int. J. Hyg. Environ. Health, vol.216, pp.271-279, 2013.
URL : https://hal.archives-ouvertes.fr/ineris-00963467

S. Zhang, J. Ma, Z. Fu, Z. Zhang, J. Cao et al., Promotion of breast cancer cells MDA-MB-231 invasion by di(2-ethylhexyl)phthalate through matrix metalloproteinase-2/-9 overexpression, Environ. Sci. Pollut. Res. Int, vol.23, pp.9742-9749, 2016.