F. Matsumura, The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects, Biochem Pharmacol, vol.77, pp.608-626, 2009.

Y. Tian, A. B. Rabson, and M. A. Gallo, Ah receptor and NF-kappaB interactions: mechanisms and physiological implications, Chem Biol Interact, vol.141, pp.97-115, 2002.

M. S. Denison and S. R. Nagy, Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, Annu Rev Pharmacol Toxicol, vol.43, pp.309-334, 2003.

E. Guyot, A. Chevallier, R. Barouki, and X. Coumoul, The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications, Drug discovery today, vol.18, pp.479-486, 2013.

J. Rainville, K. Pollard, and N. Vasudevan, Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior, Frontiers in endocrinology, vol.6, p.18, 2015.

B. Moorthy, C. Chu, and D. J. Carlin, Polycyclic aromatic hydrocarbons: from metabolism to lung cancer, Toxicol Sci, vol.145, pp.5-15, 2015.

I. C. Nisbet and P. K. Lagoy, Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regulatory toxicology and pharmacology, RTP, vol.16, pp.290-300, 1992.

C. E. Bostrom, P. Gerde, A. Hanberg, B. Jernstrom, C. Johansson et al., Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air, Environ Health Perspect, vol.110, issue.3, pp.451-488, 2002.

H. Liu, C. Xu, Z. Y. Jiang, and A. Gu, Association of polycyclic aromatic hydrocarbons and asthma among children 6-19 years: NHANES, Respiratory medicine, vol.110, pp.20-27, 2001.

A. C. Ochoa-martinez, T. Ruiz-vera, L. G. Pruneda-alvarez, A. K. Gonzalez-palomo, C. I. Almendarezreyna et al., Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Environmental science and pollution research international, vol.24, pp.1862-1870, 2017.

J. P. Incardona, T. K. Collier, and N. L. Scholz, Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons, Toxicol Appl Pharmacol, vol.196, pp.191-205, 2004.

J. P. Incardona, H. L. Day, T. K. Collier, and N. L. Scholz, Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism, Toxicol Appl Pharmacol, vol.217, pp.308-321, 2006.

Y. Zhang, C. Wang, L. Huang, R. Chen, Y. Chen et al., Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos. Aquatic toxicology, pp.119-124, 2012.

J. Øvrevik, M. Refsnes, J. A. Holme, P. E. Schwarze, and M. Lag, Mechanisms of chemokine responses by polycyclic aromatic hydrocarbons in bronchial epithelial cells: sensitization through toll-like receptor-3 priming, Toxicol Lett, vol.219, pp.125-132, 2013.

M. Iwanari, M. Nakajima, R. Kizu, K. Hayakawa, and T. Yokoi, Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissuederived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences, Arch Toxicol, vol.76, pp.287-298, 2002.

A. Mayati, L. Ferrec, E. Lagadic-gossmann, D. Fardel, and O. , Aryl hydrocarbon receptorindependent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells, Environ Toxicol, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00680889

J. Vondracek, K. Pencikova, J. Neca, M. Ciganek, A. Grycova et al., Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay, Environ Pollut, vol.220, pp.307-316, 2017.

M. G. Barron, R. Heintz, and S. D. Rice, Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish, Marine environmental research, vol.58, pp.95-100, 2004.

E. Elovaara, J. Mikkola, H. Stockmann-juvala, L. Luukkanen, H. Keski-hynnila et al., Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver, Arch Toxicol, vol.81, pp.169-182, 2007.

L. A. Hendon, E. A. Carlson, S. Manning, and M. Brouwer, Molecular and developmental effects of exposure to pyrene in the early life-stages of Cyprinodon variegatus. Comparative biochemistry and physiology Toxicology & pharmacology, CBP, vol.147, pp.205-215, 2008.

N. E. Landvik, M. Gorria, V. M. Arlt, N. Asare, A. Solhaug et al., Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects, Toxicology, vol.231, pp.159-174, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00690346

J. Øvrevik, V. M. Arlt, E. Oya, E. Nagy, S. Mollerup et al., Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells, Toxicol Appl Pharmacol, vol.242, pp.270-280, 2010.

W. H. Bisson, D. C. Koch, O. Donnell, E. F. Khalil, S. M. Kerkvliet et al., Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands, Journal of medicinal chemistry, vol.52, pp.5635-5641, 2009.

C. A. Flaveny, I. A. Murray, and G. H. Perdew, Differential gene regulation by the human and mouse aryl hydrocarbon receptor, Toxicol Sci, vol.114, pp.217-225, 2010.

C. A. Flaveny, I. A. Murray, C. R. Chiaro, and G. H. Perdew, Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice, Mol Pharmacol, vol.75, pp.1412-1420, 2009.

A. Mayati, N. Levoin, H. Paris, N. 'diaye, M. Courtois et al., Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a beta2-adrenergic receptor/adenylyl cyclase/Epac1/inositol 1,4,5-trisphosphate pathway in endothelial cells, J Biol Chem, vol.287, pp.4041-4052, 2012.

B. C. Brinchmann, L. Ferrec, E. Podechard, N. Lagadic-gossmann, D. Shoji et al., Lipophilic Chemicals from Diesel Exhaust Particles Trigger Calcium Response in Human Endothelial Cells via Aryl Hydrocarbon Receptor Non-Genomic Signalling, Int J Mol Sci, vol.19, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01795808

D. M. Owen, C. Rentero, A. Magenau, A. Abu-siniyeh, and K. Gaus, Quantitative imaging of membrane lipid order in cells and organisms, Nat Protoc, vol.7, pp.24-35, 2011.

A. Collin, K. Hardonniere, M. Chevanne, J. Vuillemin, N. Podechard et al., Cooperative interaction of benzo[a]pyrene and ethanol on plasma membrane remodeling is responsible for enhanced oxidative stress and cell death in primary rat hepatocytes, Free radical biology & medicine, vol.72, pp.11-22, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01018147

A. Perkins, J. L. Phillips, N. I. Kerkvliet, R. L. Tanguay, G. H. Perdew et al., A Structural Switch between Agonist and Antagonist Bound Conformations for a LigandOptimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain, Biology, vol.3, pp.645-669, 2014.

M. M. Totrov and R. A. Abagyan, Derivation of sensitive discrimination potential for virtual ligand screening, Proceedings of the Third Annual Intl Conf on Comp Mol Biol, pp.312-320, 1999.

H. Sekine, J. Mimura, M. Oshima, H. Okawa, J. Kanno et al., Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock, Mol Cell Biol, vol.29, pp.6391-6400, 2009.

A. Mayati, F. E. Le, J. A. Holme, O. Fardel, D. Lagadic-gossmann et al., Calcium signaling and beta2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS2B cells, Toxicol in Vitro, vol.28, pp.1153-1157, 2014.

P. Wiggins and R. Phillips, Membrane-protein interactions in mechanosensitive channels, Biophysical journal, vol.88, pp.880-902, 2005.

M. Gorria, X. Tekpli, O. Sergent, L. Huc, F. Gaboriau et al., Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol, Annals of the New York Academy of Sciences, vol.1090, pp.108-112, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00699948

B. Pani and B. B. Singh, Lipid rafts/caveolae as microdomains of calcium signaling, Cell calcium, vol.45, pp.625-633, 2009.
DOI : 10.1016/j.ceca.2009.02.009
URL : http://europepmc.org/articles/pmc2695836?pdf=render

K. J. Smith, I. A. Murray, R. Tanos, J. Tellew, A. E. Boitano et al., Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism, The Journal of pharmacology and experimental therapeutics, vol.338, pp.318-327, 2011.
DOI : 10.1124/jpet.110.178392
URL : http://jpet.aspetjournals.org/content/jpet/338/1/318.full.pdf

B. Zhao, D. E. Degroot, A. Hayashi, G. He, and M. S. Denison, CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor, Toxicol Sci, vol.117, pp.393-403, 2010.

T. Maruyama, T. Kanaji, S. Nakade, T. Kanno, and K. Mikoshiba, 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release, Journal of biochemistry, vol.122, pp.498-505, 1997.
DOI : 10.1093/oxfordjournals.jbchem.a021780

H. Saleem, S. C. Tovey, T. F. Molinski, and C. W. Taylor, Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor, Br J Pharmacol, vol.171, pp.3298-3312, 2014.

C. Zitt, B. Strauss, E. C. Schwarz, N. Spaeth, G. Rast et al., Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2, J Biol Chem, vol.279, pp.12427-12437, 2004.

L. P. He, T. Hewavitharana, J. Soboloff, M. A. Spassova, and D. L. Gill, A functional link between storeoperated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2, J Biol Chem, vol.280, pp.10997-11006, 2005.

M. Amaro, F. Reina, M. Hof, C. Eggeling, and E. Sezgin, Laurdan and Di-4-ANEPPDHQ probe different properties of the membrane, Journal of physics D: Applied physics, vol.50, p.134004, 2017.
DOI : 10.1101/076752
URL : https://www.biorxiv.org/content/early/2016/09/22/076752.full.pdf

E. J. Lim, Z. Majkova, S. Xu, L. Bachas, X. Arzuaga et al., Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells, Chem Biol Interact, vol.176, pp.71-78, 2008.
DOI : 10.1016/j.cbi.2008.08.007
URL : http://europepmc.org/articles/pmc2603293?pdf=render

J. Rey-barroso, A. Alvarez-barrientos, E. Rico-leo, M. Contador-troca, J. M. Carvajal-gonzalez et al., The Dioxin receptor modulates Caveolin-1 mobilization during directional migration: role of cholesterol, Cell Commun Signal, vol.12, p.57, 2014.

A. Adebiyi, D. Narayanan, and J. H. Jaggar, Caveolin-1 assembles type 1 inositol 1,4,5trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells, J Biol Chem, vol.286, pp.4341-4348, 2011.
DOI : 10.1074/jbc.m110.179747
URL : http://www.jbc.org/content/286/6/4341.full.pdf

P. Monteiro, D. Gilot, L. Ferrec, E. Rauch, C. Lagadic-gossmann et al., Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway, Mol Pharmacol, vol.73, pp.769-777, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00696176

R. A. Samarasinghe, D. Maio, R. Volonte, D. Galbiati, F. Lewis et al., Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation, Proceedings of the National Academy of Sciences of the United States of America, vol.108, pp.16657-16662, 2011.
DOI : 10.1073/pnas.1102821108
URL : http://www.pnas.org/content/108/40/16657.full.pdf

P. Factor, A. T. Akhmedov, J. D. Mcdonald, A. Qu, J. Wu et al., Polycyclic aromatic hydrocarbons impair function of beta2adrenergic receptors in airway epithelial and smooth muscle cells, Am J Respir Cell Mol Biol, vol.45, pp.1045-1049, 2011.

R. S. Ostrom and P. A. Insel, The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology, Br J Pharmacol, vol.143, pp.235-245, 2004.

J. A. Allen, J. Z. Yu, R. H. Dave, A. Bhatnagar, B. L. Roth et al., Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling, Mol Pharmacol, vol.76, pp.1082-1093, 2009.
DOI : 10.1124/mol.109.060160
URL : http://molpharm.aspetjournals.org/content/molpharm/76/5/1082.full.pdf

D. E. Clapham, Calcium signaling, Cell, vol.131, pp.1047-1058, 2007.

S. L. Sandow, S. Senadheera, T. H. Grayson, D. G. Welsh, and T. V. Murphy, Calcium and endotheliummediated vasodilator signaling, Adv Exp Med Biol, vol.740, pp.811-831, 2012.
DOI : 10.1007/978-94-007-2888-2_36

C. Tiruppathi, R. D. Minshall, B. C. Paria, S. M. Vogel, and A. B. Malik, Role of Ca2+ signaling in the regulation of endothelial permeability, Vascular pharmacology, vol.39, pp.173-185, 2002.

J. F. Savouret, A. Berdeaux, and R. F. Casper, The aryl hydrocarbon receptor and its xenobiotic ligands: a fundamental trigger for cardiovascular diseases. Nutrition, metabolism, and cardiovascular diseases, NMCD, vol.13, pp.104-113, 2003.

H. M. Korashy and A. O. El-kadi, The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases, Drug Metab Rev, vol.38, pp.411-450, 2006.

Z. Majkova, M. Toborek, and B. Hennig, The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants, Journal of cellular and molecular medicine, vol.14, pp.2359-2370, 2010.

J. T. Perkins, M. C. Petriello, B. J. Newsome, and B. Hennig, Polychlorinated biphenyls and links to cardiovascular disease. Environmental science and pollution research international, vol.23, pp.2160-2172, 2016.
DOI : 10.1007/s11356-015-4479-6
URL : http://europepmc.org/articles/pmc4609220?pdf=render