HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot study

Abstract : Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (< 28 days of life) who underwent cardiac surgery under cardiopulmonary bypass (CPB), which have a high risk of nosocomial infection. In this pilot study, we studied nine neonates with a diagnosis of congenital heart disease requiring surgery under CPB. There was a significant reduction in monocyte HLA-DR expression for the first two postoperative days, as compared to preoperatively (p = 0.004). Moreover, neonates who displayed an episode of NI had a dramatically lower HLA-DR expression at day 4, as compared to neonates without NI (4257 AB/c [2220-5895] vs 14,947 AB/c [9858-16,960]; p = 0.04). Our preliminary results could indicate that HLA-DR expression may be a useful biomarker of immunosuppression-induced secondary infection after CPB in neonates.
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Submitted on : Tuesday, September 25, 2018 - 2:52:48 PM
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Alexis Chenouard, Cécile Braudeau, Nicolas Cottron, Pierre Bourgoin, Nina Salabert, et al.. HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot study. INTENSIVE CARE MEDICINE EXPERIMENTAL, Springer, 2018, 6 (1), pp.S272. ⟨10.1186/s40635-017-0166-x⟩. ⟨hal-01881138⟩

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