Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department, Crit Care Med, vol.38, pp.1045-1053, 2010. ,
Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer, Acad Emerg Med, vol.17, pp.1080-1085, 2010. ,
Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study, Crit Care Med, vol.34, pp.344-353, 2006. ,
EPISEPSIS: a reappraisal of the epidemiology and outcome of severe Sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004. ,
Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department, Clin Chim Acta, vol.450, pp.169-175, 2015. ,
Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department, Clin Chim Acta, vol.452, pp.177-181, 2016. ,
Serum CXCL12 levels on hospital admission predict mortality in patients with severe sepsis/septic shock, Am J Emerg Med, vol.33, pp.1802-1804, 2015. ,
Prognostic value of plasma tight-junction proteins for sepsis in emergency department: an observational study, Shock, vol.45, pp.326-332, 2016. ,
Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units, Crit Care Med, vol.26, pp.1020-1024, 1998. ,
Febrile adults presenting to the emergency department: outcomes and markers of serious illness, Emerg Med J, vol.21, pp.170-174, 2004. ,
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study, Lancet Respir Med, vol.4, pp.259-271, 2016. ,
Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis, Clin Infect Dis, vol.44, pp.1321-1328, 2007. ,
Comparable flow cytometry data can be obtained with two types of instruments, Canto II, and Navios. A GEIL study ,
, Cytometry A, vol.83, pp.1066-1072, 2013.
Harmonemia: a universal strategy for flow cytometry immunophenotyping-A European LeukemiaNet WP10 study, Leukemia, vol.30, pp.1769-1772, 2016. ,
Circulating immature granulocytes with T-cell killing functions predict sepsis deterioration, Crit Care Med, vol.42, pp.2007-2018, 2014. ,
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, The ACCP/SCCM Consensus Conference Committee, vol.101, pp.1644-1655, 1992. ,
,
, SCCM / ESICM / ACCP / ATS / SIS International Sepsis Definitions Conference, vol.31, pp.1250-1256, 2003.
The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM, Intensive Care Med, vol.25, issue.7, pp.686-696, 1999. ,
Mortality risk prediction in sepsis, Crit Care Med, vol.23, issue.10, pp.1793-1794, 1995. ,
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA, vol.315, pp.801-810, 2016. ,
qSOFA does not replace SIRS in the definition of sepsis, Crit Care, vol.20, p.210, 2016. ,
The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients, Intensive Care Med, vol.38, pp.445-452, 2012. ,
Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis, Crit Care, vol.19, p.245, 2015. ,
CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients, J Clin Microbiol, vol.47, pp.3914-3919, 2009. ,
Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit, Crit Care, vol.14, issue.5, p.192, 2010. ,
Are there standardized cutoff values for neutrophil-lymphocyte ratios in bacteremia or sepsis?, J Microbiol Biotechnol, vol.25, issue.4, pp.521-525, 2015. ,
Circulating CD10-/CD16low neutrophils provide a quantitative index of active bone marrow neutrophil release, Br J Haematol, vol.131, pp.508-519, 2005. ,
A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation, Am J Physiol Regul Integr Comp Physiol, vol.292, pp.1707-1716, 2007. ,
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis, Crit Care, vol.11, p.49, 2007. ,
Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia, Crit Care Med, vol.39, pp.2211-2217, 2011. ,
Stability in community-acquired pneumonia: one step forward with markers?, Thorax, vol.64, pp.987-992, 2009. ,
Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow, Am J Physiol Heart Circ Physiol, vol.279, pp.2954-2960, 2000. ,
Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome, Crit Care Med, vol.41, issue.3, pp.820-832, 2013. ,
Persistent lymphopenia after diagnosis of sepsis predicts mortality, Shock, vol.42, issue.5, pp.383-391, 2014. ,
Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock, Intensive Care Med, vol.32, issue.8, pp.1175-1183, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00428008
Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study, Clin Chem, vol.51, issue.12, pp.2341-2347, 2005. ,
Immunosuppression in patients who die of sepsis and multiple organ failure, JAMA, vol.306, issue.23, pp.2594-605, 2011. ,
, Abbreviations: IG: Immature Granulocytes; OR: Odds Ratio; AUC: Area Under the Curve