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Journal articles
Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption
Abstract : Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects. To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes stimulated by interleukin-1 beta (IL-1β). The results showed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was assessed in two animal models of post-traumatic OA in mice and rabbits. Diet supplementation with HT/PCy significantly decreased the severity of post-traumatic osteoarthritis in two complementary mice and rabbit models. The bioavailability and bioactivity was evaluated following gavage with HT/PCy in rabbits. Regular metabolites from HT/PCy extract were found in sera from rabbits following oral intake. Finally, sera from rabbits force-fed with HT/PCy conserved anti-IL-1β effect, suggesting the bioactivity of this extract. To conclude, HT/PCy extract may be of clinical significance for the preventive treatment of osteoarthritis.
Cited literature [69 references]
https://hal.sorbonne-universite.fr/hal-01378502
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Submitted on : Monday, October 10, 2016 - 11:57:29 AM
Last modification on : Saturday, June 19, 2021 - 3:20:10 AM
Long-term archiving on: : Saturday, February 4, 2017 - 12:48:05 AM
Contributor : Gestionnaire Hal-Upmc Connect in order to contact the contributor
Submitted on : Monday, October 10, 2016 - 11:57:29 AM
Last modification on : Saturday, June 19, 2021 - 3:20:10 AM
Long-term archiving on: : Saturday, February 4, 2017 - 12:48:05 AM
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srep33527.pdf
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