Skip to Main content Skip to Navigation
New interface
Journal articles

Intracellular stresses in patterned cell assemblies

Abstract : Confining cells on adhesive patterns allows performing robust, weakly dispersed, statistical analysis. A priori, adhesive patterns could be efficient tools to analyze intracellular cell stress fields, in particular when patterns are used to force the geometry of the cytoskeleton. This tool could then be very helpful in deciphering the relationship between the internal architecture of the cells and the mechanical, intracellular stresses. However, the quantification of the intracellular stresses is still something delicate to perform. Here we first propose a new, very simple and original method to quantify the intracellular stresses, which directly relates the strain the cells impose on the extracellular matrix to the intracellular stress field. This method is used to analyze how confinement influences the intracellular stress field. As a result, we show that the more confined the cells are, the more stressed they will be. The influence of the geometry of the adhesive patterns on the stress patterns is also discussed.
Document type :
Journal articles
Complete list of metadata
Contributor : Marielle Clot Connect in order to contact the contributor
Submitted on : Wednesday, September 28, 2022 - 11:07:10 AM
Last modification on : Friday, September 30, 2022 - 3:52:27 AM


Publication funded by an institution




Michel Moussus, Christelle C. Der Loughian, David Fuard, Marie Courçon, Danielle Gulino-Debrac, et al.. Intracellular stresses in patterned cell assemblies. Soft Matter, 2013, 10, pp.2414-2423. ⟨10.1039/C3SM52318G⟩. ⟨hal-00949969⟩



Record views


Files downloads