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Table 2.

Relative risk (95% CI) of postmenopausal breast cancer according to quintiles of energy-adjusted Mate by intake of energy-adjusted vitamin B12

Median intakea Tertiles of energy-adjusted vitamin B12 intake
1
2
3
4.2 μg/day 6.7 μg/day 11.6 μg/day
Quintiles of folate intake Cases Age-adjusted Multivariateb Cases Age-adjusted Multivariateb Cases Age-adjusted Multivariateb
1 180 1.00 1.00 135 1.00 1.00 80 1.00 1.00
2 138 0.96(0.77–1.20) 0.92(0.74–1.15) 134 0.90(0.71–1.14) 0.90(0.71–1.14) 83 0.63 (0.47–0.86) 0.62 (0.45–0.84)
3 97 0.77 (0.60–0.99) 0.75 (0.59–0.97) 155 1.04(0.82–1.31) 1.02(0.81–1.29) 114 0.66 (0.49–0.88) 0.64 (0.48–0.86)
4 107 0.96(0.75–1.22) 0.92(0.72–1.18) 104 0.76 (0.59–0.98) 0.75 (0.58–0.97) 136 0.62 (0.47–0.82) 0.62 (0.47–0.82)
5 79 0.92(0.70–1.20) 0.92(0.70–1.20) 87 0.75 (0.57–0.98) 0.73 (0.56–0.97) 183 0.62 (0.47–0.80) 0.62 (0.47–0.81)
p-value trend 0.46 0.44 0.01 0.01 0.01 0.02
a Adjusted for total energy intake
b Adjusted for age, two-year follow-up period, region of residence, years of education (< 12, 12–15, or ≥15), family breast cancer (0, 1, or>1 first degree relatives), history of benign breast disease (yes or no), age at menarche (< 12, 12 13, or ≥14), parity (0, ≤2 and age at first birth ≤30 years, ≥3 and age at first birth ≤30 years or age at first birth >30 years), breastfeeding (none, < 7, 7–12, or ≥12 months), years since last use of oral contraceptives (never, unknown date of last use, < 25, 25–29, or ≥30), age at menopause (< 45, 45–49, 50–54, or ≥55), years of hormone replacement therapy use (never, unknown duration, < 3, 3–5.9, or ≥6), regular mammographic evaluation (yes or no), height in cm, body mass index (quartiles), vitamin (other than vitamin B) supplement use (yes or no), and physical activity (quartiles). Regular mammographic evaluation defined as a report of a recent mammogram in 1990, 1992, and 1993
Cancer Causes Control. 2006 November; 17(9): 1209–13.
doi: 10.1007/s10552-006-0053-3.