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SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

Abstract : We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a core model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the core models, the project involves database implementation and ontology development.
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Submitted on : Tuesday, June 21, 2022 - 4:56:15 PM
Last modification on : Thursday, June 23, 2022 - 11:30:46 AM


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S. Randall Thomas, Pierre Baconnier, Julie Fontecave, Jean-Pierre Françoise, François Guillaud, et al.. SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Royal Society, The, 2008, 366 (1878), pp.3175-3197. ⟨10.1098/rsta.2008.0079⟩. ⟨hal-00339613⟩



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