Loading...
Dernières publications
-
Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
-
Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
-
Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
-
Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
131
Publications avec texte intégral
Open Access
52 %
Mots clés
DMPK
Hypoxia
Motoneuron
GABA
RNA interference
Intermediate filament
Brain
CRISPR/Cas9
PCR
Genotype phenotype correlation
Oligodendrocytes
Gene Therapy
ARN
CTG repeat instability
Glutamate
Autophagy
AAV
Myotonic dystrophy mouse models
Duchenne muscular dystrophy
Desmin
Diaphragm
RNA biology
Gene therapy
KNOCKOUT MICE
Antisense oligonucleotides
Knockout
Dilated cardiomyopathy
CMS
Dystrophie myotonique
Myotonic Dystrophy Type 1
Dystrophie Myotonique
Expression
Muscle
Centronuclear myopathy
Brain dysfunction
Central nervous system
Glial cells
Acetylcholinesterase deficiency
Neuron
Thérapie génique
Transcriptomics
Glucocorticoid-receptor
Trinucleotide Repeat Expansion
GSK3
CTG repeats
Trinucleotide repeat expansion
PacBio
Exercice
Skeletal muscle
Mice
DM1
RNA splicing
ACETYLCHOLINESTERASE
Cell penetrating peptide
Alternative splicing
Humans
Fibrosis
Muscular dystrophy
Acetylcholinesterase knockout mouse
Quantitative microdialysis
Glucocorticoids
Astrocytes
CONGENITAL MYATHENIC SYNDROME
Male
Heart
Myotonic Dystrophy type 1
BIOLOGIE MOLECULAIRE
Dynamin 2
CRISPRi
Long read sequencing
Mouse model
Antisense oligonucleotide
Lc3
Exercise
Heart failure
Myotonic dystrophy
Dystrophin
Myotonic Dystrophy
Aging
Transgenic mouse model
Cell culture model
MBNL
Cell model
Therapy
Acute coronary syndrome
Oligodendrocyte
Cytoskeleton
Myostatin
Myelin
Cardiac muscle
In vivo
DMSXL mice
Gene editing
Animals
Astrocyte
Transgenic mouse
CTG repeat contractions
Myotonic dystrophy type 1
Mouse models
Maximal force