A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer - Centre de recherche Saint-Antoine - UMR S938 Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2021

A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer

Résumé

Scaffolding molecules exert a critical role in orchestrating cellular response through the spatiotemporal assembly of effector proteins as signalosomes. By increasing the efficiency and selectivity of intracellular signaling, these molecules can exert (anti/pro)oncogenic activities. As an archetype of scaffolding proteins with tumor suppressor property, the present review focuses on MAGI1, 2, and 3 (membrane-associated guanylate kinase inverted), a subgroup of the MAGUK protein family, that mediate networks involving receptors, junctional complexes, signaling molecules, and the cytoskeleton. MAGI1, 2, and 3 are comprised of 6 PDZ domains, 2 WW domains, and 1 GUK domain. These 9 protein binding modules allow selective interactions with a wide range of effectors, including the PTEN tumor suppressor, the β-catenin and YAP1 proto-oncogenes, and the regulation of the PI3K/AKT, the Wnt, and the Hippo signaling pathways. The frequent downmodulation of MAGIs in various human malignancies makes these scaffolding molecules and their ligands putative therapeutic targets. Interestingly, MAGI1 and MAGI2 genetic loci generate a series of long non-coding RNAs that act as a tumor promoter or suppressor in a tissue-dependent manner, by selectively sponging some miRNAs or by regulating epigenetic processes. Here, we discuss the different paths followed by the three MAGIs to control carcinogenesis.
Fichier principal
Vignette du fichier
cancers-13-04264-v2.pdf (24.99 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03350218 , version 1 (21-09-2021)

Identifiants

Citer

Larissa Kotelevets, Eric Chastre. A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer. Cancers, 2021, 13 (17), pp.4264. ⟨10.3390/cancers13174264⟩. ⟨hal-03350218⟩
38 Consultations
61 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More