Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

A new local score based method applied to behavior-divergent quail lines sequenced in pools precisely detects selection signatures on genes related to autism

Abstract : Detecting genomic footprints of selection is an important step in the understanding of evolution. Accounting for linkage disequilibrium in genome scans allows increasing the detection power, but haplotype-based methods require individual genotypes and are not applicable on pool-sequenced samples. We propose to take advantage of the local score approach to account for linkage disequilibrium, accumulating (possibly small) signals from single markers over a genomic segment, to clearly pinpoint a selection signal, avoiding windowing methods. This method provided results similar to haplotype-based methods on two benchmark data sets with individual genotypes. Results obtained for a divergent selection experiment on behavior in quail, where two lines were sequenced in pools, are precise and biologically coherent, while competing methods failed: our approach led to the detection of signals involving genes known to act on social responsiveness or autistic traits. This local score approach is general and can be applied to other genome-wide analyzes such as GWAS or genome scans for selection.
Document type :
Preprints, Working Papers, ...
Complete list of metadata

Cited literature [58 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01194146
Contributor : Archive Ouverte Prodinra <>
Submitted on : Friday, June 5, 2020 - 5:38:34 PM
Last modification on : Monday, July 19, 2021 - 4:19:24 PM

File

2015_MIFariello_ArXiv_1.pdf
Files produced by the author(s)

Identifiers

Citation

Maria Inès Fariello Rico, Simon Boitard, Sabine Mercier, David Robelin, Thomas Faraut, et al.. A new local score based method applied to behavior-divergent quail lines sequenced in pools precisely detects selection signatures on genes related to autism. 2015. ⟨hal-01194146⟩

Share

Metrics

Record views

1008

Files downloads

29