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Metabolic Reprogramming, Questioning, and Implications for Cancer

Pierre Jacquet 1 Angélique Stéphanou 1
1 TIMC-DyCTiM - Dynamique Cellulaire et Tissulaire- Interdisciplinarité, Modèles & Microscopies
TIMC - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : The expression “metabolic reprogramming” has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be used as a “catch-all” expression. Our first intention is to point out the inconsistencies in the use of the reprogramming terminology for cancer metabolism. The second is to address the over-focus of the role of mutations in metabolic adaptation. With the increased interest in metabolism and, more specifically, in the Warburg effect in cancer research, it seems appropriate to discuss this terminology and related concepts in detail.
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Contributor : Angélique Stéphanou <>
Submitted on : Wednesday, February 24, 2021 - 2:30:54 PM
Last modification on : Friday, April 2, 2021 - 11:31:07 AM


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Pierre Jacquet, Angélique Stéphanou. Metabolic Reprogramming, Questioning, and Implications for Cancer. Biology, MDPI 2021, 10 (2), pp.129. ⟨10.3390/biology10020129⟩. ⟨hal-03151101⟩



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