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Environmental exposures related to parental habits in the perinatal period and the risk of Wilms' tumor in children

Anne Notz-Carrere 1 Paula Rios 2, * Helene Bauer 2 Gudrun Schleiermacher 3 Claudia Pasqualini 4, 5, 6 Cecile Boulanger 7 Estelle Thébaud 8 Virginie Gandemer 9, 10 Isabelle Pellier 11 Arnauld Verschuur 12 Hélène Sudour-Bonnange 13, 14 Aurore Coulomb-l'Hermine 15 Alexandra Spiegel 16 Anne Notz- Carrere Christophe Bergeron 17 Laurent Orsi 2 Brigitte Lacour 2 Jacqueline Clavel 2
* Corresponding author
1 CHU Bordeaux [Bordeaux]
2 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
3 Institut Curie [Paris]
4 Université Paris-Saclay
5 IGR - Institut Gustave Roussy
6 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
7 CHU Toulouse [Toulouse]
8 CHU Nantes - Centre hospitalier universitaire de Nantes
9 CHU Pontchaillou [Rennes]
10 IGDR - Institut de Génétique et Développement de Rennes
11 CHU Angers - Centre Hospitalier Universitaire d'Angers
12 AP-HM - Assistance Publique-Hôpitaux de Marseille
13 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
14 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]
15 Service de pathologie [CHU Trousseau]
16 CHU Strasbourg
17 Centre Léon Bérard [Lyon]
Abstract : Introduction Wilms' tumor is the most frequently diagnosed renal tumor in children. Little is known about its etiology. The aim of this study was to investigate the potential role of specific exposures related to parental habits such as parental smoking, maternal alcohol consumption and the use of household pesticides during pregnancy. Methods The ESTELLE study was a nationwide case-control study that included 117 Wilms' tumor cases and 1100 control children from the general French population, frequency-matched by age and gender. Unconditional logistic regression was used to estimate odds ratios and 95 % confidence intervals. Results After controlling for matching variables and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with the risk of Wilms' tumor in children (OR 1.6 [95 % CI 1.1-2.3]). Insecticides were the most commonly reported type of pesticide and there was a positive association with their use (OR 1.7 [95 % CI 1.1-2.6]. The association was stronger when they were used more often than once a month (OR 1.9 [95 % CI 1.2-3.0]. Neither maternal smoking during pregnancy nor paternal smoking during preconception/pregnancy was associated with a risk of Wilms' tumor (ORs 1.1[95 % CI 0.7-1.8] and 1.1 [95 % CI 0.7-1.7], respectively). No association was observed with maternal alcohol intake during pregnancy (OR 1.2 [95 % CI 0.8-2.0]). Conclusion Our findings suggest an association between the maternal use of household pesticides during pregnancy and the risk of Wilms' tumor.
Keywords : Wilms' tumor Etiology Pesticides Smoking Alcohol Childhood cancer Pregnancy Case-control study
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https://hal.archives-ouvertes.fr/hal-02887224
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, March 2, 2021 - 4:26:38 PM
Last modification on : Thursday, April 15, 2021 - 3:08:12 PM

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UNIV-RENNES1 | CURIE | LAMBRET | PSL | UNAM | IGDR | RNTSE | FNCLCC | BIOSIT | UNIV-RENNES | CNAM | CNRS | INRAE | UNIV-PARIS | UP-SANTE | UR1-UFR-SVE | UNIV-HESAM | SORBONNE-UNIVERSITE | SU-TI | IGR

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Anne Notz-Carrere, Paula Rios, Helene Bauer, Gudrun Schleiermacher, Claudia Pasqualini, et al.. Environmental exposures related to parental habits in the perinatal period and the risk of Wilms' tumor in children. Cancer Epidemiology, Elsevier, 2020, 66, pp.101706. ⟨10.1016/j.canep.2020.101706⟩. ⟨hal-02887224v2⟩

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