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In vivo estimation of normal left ventricular stiffness and contractility based on routine cine MR acquisition

Gerardo Rumindo 1 Jacques Ohayon 2 Pierre Croisille 1 Patrick Clarysse 3, 4
2 TIMC-DyCTiM - Dynamique Cellulaire et Tissulaire- Interdisciplinarité, Modèles & Microscopies
TIMC - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
3 MYRIAD - Modeling & analysis for medical imaging and Diagnosis
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
4 MOTIVATE - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé : 139739
Abstract : Post-myocardial infarction remodeling process is known to alter the mechanical properties of the heart. Biomechanical parameters, such as tissue stiffness and contractility, would be useful for clinicians to better assess the severity of the diseased heart. However, these parameters are difficult to obtain in the current clinical practice. In this paper, we estimated subject-specific in vivo myocardial stiffness and contractility from 21 healthy volunteers, based on left ventricle models constructed from data acquired from routine cardiac MR acquisition only. The subject-specific biomechanical parameters were quantified using an inverse finite-element modelling approach. The personalized models were evaluated against relevant clinical metrics extracted from the MR data, such as circumferential strain, wall thickness and fractional thickening. We obtained the ranges of healthy biomechanical indices of 1.60 ± 0.22 kPa for left ventricular stiffness and 95.13±14.56 kPa for left ventricular contractility. These reference normal values can be used for future model-based investigation on the stiffness and contractility of ischemic myocardium.
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Submitted on : Monday, January 11, 2021 - 10:59:46 AM
Last modification on : Tuesday, March 23, 2021 - 10:12:06 AM
Long-term archiving on: : Monday, April 12, 2021 - 6:14:38 PM

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Gerardo Rumindo, Jacques Ohayon, Pierre Croisille, Patrick Clarysse. In vivo estimation of normal left ventricular stiffness and contractility based on routine cine MR acquisition. Medical Engineering and Physics, Elsevier, 2020, 85, pp.16-26. ⟨10.1016/j.medengphy.2020.09.003⟩. ⟨hal-03093687⟩

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