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Article Dans Une Revue Infectious Diseases Now Année : 2021

Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population

Xavier de Lamballerie
Sapris-Sero Study Group
  • Fonction : Auteur

Résumé

This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France. Patients and methods A serosurvey was conducted in 9,782 subjects from two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data. Results IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), but also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%). Conclusions These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.
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hal-03134354 , version 1 (08-02-2021)

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Paternité - Pas d'utilisation commerciale

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Nathanael Lapidus, Juliette Paireau, Daniel Levy-Bruhl, Xavier de Lamballerie, Gianluca Severi, et al.. Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population. Infectious Diseases Now, 2021, 51 (4), pp.380-382. ⟨10.1016/j.idnow.2020.12.007⟩. ⟨hal-03134354⟩
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