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Article Dans Une Revue Insect Molecular Biology Année : 2013

First screening of Aedes albopictus immunogenic salivary proteins

S. Cornelie
Martial Séveno
F. Remoue

Résumé

Study of the human antibody (Ab) response to Aedes salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus- and/or species-specific proteins is necessary to improve the accuracy of biomarkers. We analysed Aedes albopictus immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to Ae. albopictus or Ae. aegypti bites. Strong antigenicity to Ae. albopictus salivary proteins was detected in all individuals whatever the nature of Aedes exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of Ae. albopictus immunogenic salivary proteins for the first time.

Dates et versions

hal-01274584 , version 1 (16-02-2016)

Identifiants

Citer

Souleymane Doucouré, S. Cornelie, S. Patramool, F. Mouchet, Edith Demettre, et al.. First screening of Aedes albopictus immunogenic salivary proteins. Insect Molecular Biology, 2013, 22 (4), pp.411--423. ⟨10.1111/imb.12032⟩. ⟨hal-01274584⟩
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