PMID (identifiant
de la référence Pubmed) : |
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 (22052329) |
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| Titre : |
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Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case-control studies. |
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| Auteur(s) : |
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Beate Pesch ( ) 1, Benjamin Kendzia1, Per Gustavsson2, Karl-Heinz Jöckel3, Georg Johnen1, Hermann Pohlabeln4, Ann Olsson2, 5, Wolfgang Ahrens4, Isabelle Mercedes Gross1, Irene Brüske6, Heinz-Erich Wichmann6, Franco Merletti7, Lorenzo Richiardi7, Lorenzo Simonato8, Cristina Fortes9, Jack Siemiatycki10, Marie-Elise Parent10, 11, Dario Consonni12, Maria Teresa Landi13, Neil Caporaso13, David Zaridze14, Adrian Cassidy15, Neonila Szeszenia-Dabrowska16, Peter Rudnai17, Jolanta Lissowska18, Isabelle Stücker19, Eleonora Fabianova20, Rodica Stanescu Dumitru21, Vladimir Bencko22, Lenka Foretova23, Vladimir Janout24, Charles M Rudin25, Paul Brennan5, Paolo Boffetta26, 27, Kurt Straif5, Thomas Brüning1 |
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| Laboratoire : |
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| 1 : |
IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance |
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| Institute of Ruhr Universität Bochum |
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| Bochum |
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| Allemagne |
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| 2 : |
IMM - The Institute of Environmental Medicine [Stockholm] |
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| Karolinska Institutet |
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| SE-171 77 Stockholm, Sweden |
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| Suède |
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| 3 : |
Institute for Medical Informatics, Biometry, and Epidemiology |
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| University Hospital of Essen |
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| Essen |
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| Allemagne |
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| 4 : |
Bremen Institute for Prevention Research and Social Medicine |
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| University of Bremen |
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| Bremen |
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| Allemagne |
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| 5 : |
IACR - International Agency for Cancer Research |
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| http://www.iarc.fr/ |
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| International Agency for Cancer Research, |
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| 150 Cours Albert Thomas, 69372 Lyon CEDEX 08 |
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| France |
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| 6 : |
Institute of Epidemiology |
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| HelmholtzZentrum München |
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| München |
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| Allemagne |
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| 7 : |
Cancer Epidemiology Unit |
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| CPO-Piemonte – Université de Turin |
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| Turin |
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| Italie |
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| 8 : |
Department of Environmental Medicine and Public Health |
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| University of Padova |
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| Padova |
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| Italie |
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| 9 : |
Clinical Epidemiology Unit |
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| IDI-IRCCS |
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| Rome |
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| Italie |
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| 10 : |
CRCHUM - University of Montreal Hospital Research Center |
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| School of public health |
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| Montreal |
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| Canada |
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| 11 : |
IAF - Institut Armand Frappier |
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| http://www.iaf.inrs.ca |
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| Institut National de la Recherche Scientifique – Réseau International des Instituts Pasteur |
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| 531 boul. des Prairies Laval (Québec) H7V 1B7 |
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| Canada |
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| 12 : |
Unit of Epidemiology |
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| Fondazione IRCCS Ca' Granda – Ospedale Maggiore Policlinico |
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| Milan |
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| Italie |
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| 13 : |
Division of Cancer Epidemiology and Genetics |
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| National Cancer Institute |
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| Bethesda, Maryland |
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| États-Unis |
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| 14 : |
Institute of Carcinogenesis |
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| Russian Cancer Research Centre |
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| Moscow |
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| Russie, Fédération De |
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| 15 : |
Roy Castle Lung Cancer Research Programme |
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| Cancer Research Centre – University of Liverpool |
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| Liverpool |
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| Royaume-Uni |
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| 16 : |
The Nofer Institute of Occupational Medicine |
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| The Nofer Institute of Occupational Medicine |
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| Lodz |
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| Pologne |
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| 17 : |
National Institute of Environment Health |
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| National Institute of Environment Health |
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| Budapest |
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| Hongrie |
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| 18 : |
The M Sklodowska-Curie Cancer Center |
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| Institute of Oncology |
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| Warsaw |
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| Pologne |
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| 19 : |
Epidémiologie environnementale des cancers |
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| http://ifr69.vjf.inserm.fr/u754/ |
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| INSERM : IFR69 – Université Paris XI - Paris Sud |
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| 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF CEDEX |
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| France |
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| 20 : |
Department of Occupational Health |
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| Specialized State Health Institute – Regional Authority of Public Health |
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| Banska Bystrica |
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| Slovaquie |
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| 21 : |
National Institute of Public Health |
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| National Institute of Public Health |
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| Bucharest |
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| Roumanie |
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| 22 : |
Institute of Hygiene and Epidemiology |
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| 1st Faculty of Medicine – Charles University |
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| Prague |
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| Tchèque, République |
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| 23 : |
Masaryk Memorial Cancer Institute |
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| Masaryk Memorial Cancer Institute |
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| Brno |
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| Tchèque, République |
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| 24 : |
Department of Preventive Medicine |
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| Palacky university – Faculty of Medicine |
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| Olomouc |
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| Tchèque, République |
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| 25 : |
The Sidney Kimmel Comprehensive Cancer Center |
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| Johns Hopkins |
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| Baltimore, Maryland |
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| États-Unis |
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| 26 : |
The Tisch Cancer Institute |
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| Mount Sinai School of Medicine |
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| New York |
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| États-Unis |
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| 27 : |
International Prevention Research Institute |
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| International Prevention Research Institute |
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| Lyon |
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| France |
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| Résumé : |
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Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age-adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8-143.2) for SqCC, 111.3 (95% CI: 69.8-177.5) for SCLC and 21.9 (95% CI: 16.6-29.0) for AdCa. In women, the corresponding ORs were 62.7 (95% CI: 31.5-124.6), 108.6 (95% CI: 50.7-232.8) and 16.8 (95% CI: 9.2-30.6), respectively. Although ORs started to decline soon after quitting, they did not fully return to the baseline risk of never smokers even 35 years after cessation. The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development. |
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| Domaine : |
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Sciences du Vivant/Cancer
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Langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0020-7136 |
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| Type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1002/ijc.27339 |
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| Journal : |
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| International Journal of Cancer (Int J Cancer) |
| Publisher |
Wiley-Blackwell |
| ISSN |
0020-7136 (eISSN : 1097-0215) |
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| Audience : |
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internationale |
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| Date de publication : |
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01/09/2012 |
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Date de publication
électronique : |
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14/12/2011 |
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| Volume : |
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131 |
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| Numéro : |
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5 |
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| Page, identifiant, ... : |
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1210-9 |
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| Mots Clés : |
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cigarette smoking – lung cancer – relative risk characterization – tobacco smoke – stem cells |
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| Contrat, financement : |
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Grant sponsor: German Social Accident Insurance; Grant number: FP 271; Grant sponsors: Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology and the Ministry of Labour and Social Affairs, EC's INCO-COPERNICUS Program, Polish State Committee for Science Research, Roy Castle Foundation, NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA |
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