PMID: identifiant
de la référence Pubmed : |
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 (21444833) |
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| titre : |
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Arterial stiffness, physical function, and functional limitation: the Whitehall II Study. |
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| auteur(s) : |
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Eric Brunner ( ) 1, Martin Shipley1, Daniel Witte2, Archana Singh-Manoux1, 3, 4, Annie Britton1, Adam Tabak1, 5, Carmel Mceniery6, Ian Wilkinson6, Mika Kivimaki1 |
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| laboratoire : |
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| titre abrégé : |
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Arterial Stiffness and Functioning |
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| résumé : |
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Arterial stiffness has been proposed as an indicator of vascular aging. We aimed to examine this concept by analyzing associations of arterial stiffness with age, subjective and objective measures of physical functioning, and self-reported functional limitation. We measured aortic pulse wave velocity by applanation tonometry among 5392 men and women aged 55 to 78 years. Arterial stiffness was strongly associated with age (mean difference [SE] per decade: men, 1.37 m/s [0.06 m/s]; women: 1.39 m/s [0.10 m/s]). This association was robust to individual and combined adjustment for pulse pressure, mean arterial pressure, antihypertensive treatment, and chronic disease. Participants took an 8.00-ft (2.44-m) walking speed test, a spirometry lung function test, and completed health functioning and (instrumental) activities of daily living questionnaires. Associations of stiffness and blood pressure with physical function scores scaled to SD of 10 were compared. One-SD higher stiffness was associated with lower walking speed (coefficient [95% CI]: -0.96 [-1.29 to -0.64] m/s) and physical component summary score (-0.91 [-1.21 to -0.60]) and poorer lung function (-1.23 [-1.53 to -0.92] L) adjusted for age, sex, and ethnic group. Pulse pressure and mean arterial pressure were linked inversely only with lung function. Associations of stiffness with functional limitation were robust to multiple adjustment, including pulse pressure and chronic disease. In conclusion, the concept of vascular aging is reinforced by the observation that arterial stiffness is a robust correlate of physical functioning and functional limitation in early old age. The nature of the link between arterial stiffness and quality of life in older people merits attention. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0194-911X |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1161/HYPERTENSIONAHA.110.168864 |
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| journal : |
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| Hypertension (Hypertension) |
| Publisher |
American Heart Association |
| ISSN |
0194-911X (eISSN : 1524-4563) |
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| Audience : |
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internationale |
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| date de publication : |
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05/2011 |
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date de publication
électronique : |
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28/03/2011 |
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| volume : |
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57 |
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| numéro : |
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5 |
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| page, identifiant, ... : |
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1003-9 |
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| mots-clés auteur : |
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Epidemiology – aging – physical function – functional limitation – arterial stiffness – pulse pressure |
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| Descripteur(s) MeSH : |
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Activities of Daily Living – Age Factors – Aged – Aging – Aorta – Blood Flow Velocity – Blood Pressure – Female – Humans – Longitudinal Studies – Male – Middle Aged – Motor Activity – Pulsatile Flow – Questionnaires – Vascular Resistance |
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| contrat, financement : |
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The Whitehall II study has been supported by grants from the British Medical Research Council; British Economic and Social Research Council; British Heart Foundation; Stroke Association; UK Health and Safety Executive; UK Department of Health; National Heart Lung and Blood Institute (HL36310), US, National Institutes of Health: National Institute on Aging (R01AG013196; R01AG034454, US, National Institutes of Health; Agency for Health Care Policy Research (HS06516); and the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health. ARB, EJB, MK, CMM (Intermediate Research Fellowship), MJS and IBW (Senior Clinical Fellowship) are supported by the British Heart Foundation. MK is supported by BUPA and the Academy of Finland. EJB and ARB are supported by the Stroke Association. IBW and CMM are supported by the Cambridge Biomedical Research Centre (NIHR). |
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