PMID: identifiant
de la référence Pubmed : |
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 (19918011)  |
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| titre : |
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Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort. |
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| auteur(s) : |
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Blandine De Lauzon-Guillain1, Beverley Balkau2, Marie-Aline Charles2, Isabelle Romieu3, Marie-Christine Boutron-Ruault1, Françoise Clavel-Chapelon ( ) 1 |
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| laboratoire : |
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| titre abrégé : |
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Body silhouette history and incident diabetes |
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| résumé : |
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OBJECTIVE: Obesity and increases in body weight in adults are considered to be among the most important risk factors for type 2 diabetes. Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood. RESEARCH DESIGN AND METHODS: Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) is a cohort study of French women born in 1925-1950 and followed by questionnaire every 2 years. At baseline, in 1990, women were asked to report their current weight, height, and body silhouette at various ages. Birth weight was recorded in 2002. Cases of diabetes were self-reported or obtained by drug reimbursement record linkage and further validated. RESULTS: Of the 91,453 women who were nondiabetic at baseline, 2,534 developed diabetes over the 15 years of follow-up. Birth weight and body silhouette at 8 years, at menarche, and in young adulthood (20-25 years) were inversely associated with the risk of diabetes, independently of adult BMI during follow-up (all P(trend) < 0.001). In mid-adulthood (35-40 years), the association was reversed, with an increase in risk related to a larger body silhouette. An increase in body silhouette from childhood to mid-adulthood amplified the risk of diabetes. CONCLUSIONS: Low birth weight and thinness until young adulthood may increase the risk of diabetes, independently of adult BMI during follow-up. Young women who were lean children should be especially warned against weight gain. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1935-5548 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.2337/dc09-1304 |
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| journal : |
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| Diabetes Care (Diabetes Care) |
| Publisher |
American Diabetes Association |
| ISSN |
0149-5992 (eISSN : 0149-5992) |
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| Audience : |
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internationale |
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| date de publication : |
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02/2010 |
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date de publication
électronique : |
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16/11/2009 |
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| volume : |
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33 |
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| numéro : |
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2 |
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| page, identifiant, ... : |
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298-303 |
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| mots-clés auteur : |
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adult – adiposity – epidemiology – longitudinal |
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| Descripteur(s) MeSH : |
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Adult – Birth Weight – Body Mass Index – Body Size – Body Surface Area – Cohort Studies – Diabetes Mellitus – France – Humans – Infant – Low Birth Weight – Newborn – Male – Middle Aged – Proportional Hazards Models – Questionnaires – Regression Analysis – Thinness – Weight Gain – Young Adult |
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| contrat, financement : |
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This work was carried out with the financial support of the “Mutuelle Générale de l'Education Nationale” (MGEN); European Community; French League against Cancer (LNCC); Gustave Roussy Institute (IGR); French Institute of Health and Medical Research (Inserm); and several General Councils in France. The validation of potential diabetes cases was supported by the European Union (Integrated Project LSHM-CT-2006-037197 in the Framework Program 6 of the European-Community), InterAct project. |
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