PMID: identifiant
de la référence Pubmed : |
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 (19810107)  |
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| titre : |
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Occupational exposures contribute to educational inequalities in lung cancer incidence among men: Evidence from the EPIC prospective cohort study. |
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| auteur(s) : |
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Gwenn Menvielle ( ) 1, 2, 3, Hendriek Boshuizen2, Anton Kunst3, Paolo Vineis4, 5, Susanne Dalton6, Manuela Bergmann7, Silke Hermann8, Fabrizio Veglia9, Pietro Ferrari10, Kim Overvad11, Ole Raaschou-Nielsen6, Anne Tjønneland6, Rudolf Kaaks8, Jakob Linseisen8, 12, Domenico Palli13, Vittorio Krogh14, Rosario Tumino15, Laudina Rodriguez16, Antonio Agudo17, Maria-José Sánchez18, 19, Jone Miren Altzibar Arozena19, 20, Lluis Cirera19, 21, Eva Ardanaz19, 22, Sheila Bingham23, Kay-Tee Khaw23, Paolo Boffetta10, Eric Duell10, Nadia Slimani10, Valentina Gallo5, Elio Riboli5, H Bas Bueno-de-Mesquita2 |
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| laboratoire : |
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| titre abrégé : |
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Occupation and educational inequalities in lung cancer |
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| résumé : |
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The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses were based on a subsample of the European Prospective Investigation into Cancer and Nutrition (EPIC study), a prospective cohort. The analyses included 703 incident lung cancer cases among men in Denmark, the United Kingdom, Germany, Italy, Spain and Greece. The socioeconomic position was measured using the highest level of education. The estimates of relative indices of inequality (RII) were computed with Cox regression models. We first adjusted for smoking (with detailed information on duration and quantity) and dietary factors (fruits and vegetables consumption) and then for occupational exposures. The exposure to three carcinogens [asbestos, heavy metals and polycyclic aromatic hydrocarbons (PAH)] was analyzed. The occupational exposures explained 14% of the socioeconomic inequalities remaining after adjustment for smoking and fruits and vegetables consumption. The inequalities remained nevertheless statistically significant. The RII decreased from 1.87 (95% CI: 1.36-2.56) to 1.75 (1.27-2.41). The decrease was more pronounced when adjusting for asbestos than for heavy metals or PAH. Analyses by birth cohort suggested an effect of occupational exposures among older men, while due to small number of endpoints, no conclusion could be drawn about the role of occupational exposures in educational inequalities among younger men. Our study revealed that the impact of occupational exposures on socioeconomic inequalities in cancer incidence, rarely studied until now, exists while of modest magnitude. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0020-7136 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1002/ijc.24924 |
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| journal : |
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| International Journal of Cancer (Int J Cancer) |
| Publisher |
Wiley-Blackwell |
| ISSN |
0020-7136 (eISSN : 1097-0215) |
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| Audience : |
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internationale |
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| date de publication : |
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15/04/2010 |
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date de publication
électronique : |
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06/10/2009 |
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| volume : |
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126 |
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| numéro : |
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8 |
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| page, identifiant, ... : |
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1928-35 |
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| mots-clés auteur : |
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Lung cancer incidence – education – men – occupational exposure |
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| Descripteur(s) MeSH : |
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Cohort Studies – Educational Status – Humans – Incidence – Lung Neoplasms – Male – Occupational Exposure – Proportional Hazards Models – Prospective Studies – Socioeconomic Factors |
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