PMID: identifiant
de la référence Pubmed : |
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 (19744554) |
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| titre : |
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Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery. |
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| auteur(s) : |
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Nadia Abdelouahab1, Guy Huel2, Alexander Suvorov1, Bernard Foliguet3, Valérie Goua4, Ginette Debotte2, Josiane Sahuquillo2, Marie-Aline Charles2, Larissa Takser ( ) 1 |
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| laboratoire : |
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| résumé : |
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BACKGROUND: Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. OBJECTIVE: To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. METHODS: The study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium (Cd) determination. Mercury (Hg) was also analysed in maternal hair. Placental samples were stored immediately after expulsion and total MAO activity was measured. RESULTS: MAO activity was significantly positively correlated with maternal and cord blood Mn concentrations in subjects with high MAO activity. In subjects with low MAO activity, maternal hair Hg was negatively correlated with MAO. CONCLUSION: Our results suggest the use of placental MAO as a potential surrogate marker of Mn toxicity in the newborn and its correlation with psychomotor development should be further investigated. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1872-9738 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1016/j.ntt.2009.08.010 |
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| journal : |
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Neurotoxicol. Teratol. |
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| Audience : |
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internationale |
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| date de publication : |
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08/09/2009 |
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date de publication
électronique : |
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08/09/2009 |
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| volume : |
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32 |
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| numéro : |
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2 |
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| page, identifiant, ... : |
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256-61 |
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| mots-clés auteur : |
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manganese – lead – cadmium – mercury – monoamine oxidase – pregnancy |
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| Descripteur(s) MeSH : |
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Adult – Biological Markers – Cadmium – Cohort Studies – Delivery – Obstetric – Environmental Exposure – Female – Humans – Infant – Newborn – Lead – Manganese – Mercury – Metals – Heavy – Monoamine Oxidase – Neurotoxicity Syndromes – Placenta – Pregnancy – Prenatal Exposure Delayed Effects – RNA – Messenger – Young Adult |
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