PMID: identifiant
de la référence Pubmed : |
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 (20019901)  |
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| titre : |
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Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study. |
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| auteur(s) : |
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Chadi Yazbeck ( ) 1, 2, Olivier Thiébaugeorges3, Thierry Moreau1, Valérie Goua4, Ginette Debotte1, Josiane Sahuquillo1, Anne Forhan1, Bernard Foliguet3, Guillaume Magnin4, Rémy Slama5, Marie-Aline Charles1, Guy Huel1 |
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| laboratoire : |
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| Équipe de recherche : |
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INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire) |
| titre abrégé : |
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Lead and Gestational Hypertension |
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| résumé : |
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BACKGROUND: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure. OBJECTIVE: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy. METHODS: One thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l' Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation. RESULTS: PIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean +/- SD, 2.2 +/- 1.4 mug/dL) than in normotensive patients (1.9 +/- 1.2 mug/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1-9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation. CONCLUSIONS: These findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0091-6765 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1289/ehp.0800488 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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10/2009 |
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date de publication
électronique : |
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26/06/2009 |
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| volume : |
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117 |
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| numéro : |
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10 |
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| page, identifiant, ... : |
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1526-30 |
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| mots-clés auteur : |
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cadmium – environmental health – epidemiology – gestation – hypertension – lead – manganese. |
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| contrat, financement : |
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French Agency for Occupational and Environmental Health Safety (AFSSET), French National Institute for Population Health Surveillance (InVS), Univ. Paris– Sud, French National Institute for Health Education (INPES), Nestlé, Mutuelle Générale de l'Education Nationale (MGEN), French speaking association for the study of diabetes and metabolism (Alfediam), and French Research Agency (ANR). |
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