PMID: identifiant
de la référence Pubmed : |
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 (19198042)  |
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| titre : |
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Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa. |
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| auteur(s) : |
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Séverin-Guy Mahiane1, Camille Legeai2, Dirk Taljaard3, Aurélien Latouche4, Adrian Puren5, Aurélie Peillon6, Jean Bretagnolle7, Pascale Lissouba6, Eugène-Patrice Ndong Nguéma1, Elisabeth Gassiat7, Bertran Auvert ( ) 2, 4, 6 |
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| laboratoire : |
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| titre abrégé : |
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HSV-2, HIV and male circumcision |
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| résumé : |
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OBJECTIVES: A synergy between HIV and herpes simplex virus type 2 (HSV-2) infections has been reported in observational studies. The objectives of this study were to estimate the per-sex-act female-to-male transmission probabilities (FtoMTPs) of HIV and HSV-2, the effect of each infection on the FtoMTP of the other and the effect of male circumcision on these FtoMTPs. DESIGN: We used longitudinal data collected during the male circumcision trial conducted in Orange Farm (South Africa). METHODS: Results were obtained by specific mathematical modeling of HIV and HSV-2 statuses of the men as functions of their sexual behavior and male circumcision status. The model took into account an estimation of the HIV and HSV-2 statuses of each of their female partners. Confidence intervals (CI) were estimated using a bootstrap resampling method. RESULTS: The HIV and HSV-2 FtoMTPs, during an unprotected sexual contact for an uncircumcised male in the absence of the other virus in both partners, were 0.0047 (95% CI: 0.0014-0.017) and 0.0067 (95% CI: 0.0028-0.014), respectively. HSV-2 in either partner increased HIV FtoMTP with a relative risk (RR) of 3.0 (95% CI: 1.01-7.3). Conversely, HIV in either partner increased HSV-2 FtoMTP (RR= 2.5; 95% CI: 1.1- 6.3). Male circumcision significantly decreased these probabilities with RRs of 0.24 (95% CI: 0.11-0.44) and 0.59 (95% CI: 0.36-0.91), respectively. CONCLUSION: This study gave the first estimates of HSV-2 per-sex-act FtoMTPs in Africa. It demonstrated a synergy between HIV and HSV-2 infections and a protective effect of male circumcision on HSV-2 acquisition by males. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1473-5571 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| journal : |
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| AIDS (AIDS) |
| Publisher |
Lippincott, Williams & Wilkins |
| ISSN |
0269-9370 |
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| Audience : |
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internationale |
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| date de publication : |
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28/01/2009 |
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| volume : |
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23 |
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| numéro : |
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3 |
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| page, identifiant, ... : |
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377-383 |
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| mots-clés auteur : |
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HSV-2 – HIV – male circumcision – mathematical modeling – heterosexual transmission |
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| contrat, financement : |
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ANRS grant 1265 (France), Gates Foundation (USA) grant 33759, NICD (South Africa), INSERM (France), SACEMA (South Africa), SCAC (France Embassy, Cameroon). |
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