PMID: identifiant
de la référence Pubmed : |
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 (17519811) |
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| titre : |
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[Environmental factors for asthma severity and allergy: results from the EGEA study] |
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| auteur(s) : |
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Valérie Siroux ( ) 1, Marie-Pierre Oryszczyn2, Raphaëlle Varraso2, Nicole Le Moual2, Jean Bousquet3, Denis Charpin4, Frédéric Gormand5, Susan Kennedy6, Jean Maccario2, Christophe Pison7, Estelle Rage2, Pierre Scheinmann8, Daniel Vervloet9, Isabelle Pin1, Francine Kauffmann2, EGEA Collaboration(s) |
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| laboratoire : |
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| titre abrégé : |
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Environnement, asthme sévère, allergie : EGEA |
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| résumé : |
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INTRODUCTION: EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article. METHODS AND RESULTS: The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy (eosinophils, IgE and atopy) and hormonal dependent events in women (premenstrual asthma, menopause and oral contraceptive use) have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis. CONCLUSIONS: New hypothesis will be tested in the near future from the second stage of this survey. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Français |
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| ISSN : |
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0761-8425 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| journal : |
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| Revue des Maladies Respiratoires (Rev Mal Respir) |
| Publisher |
Elsevier Masson |
| ISSN |
0761-8425 |
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| Audience : |
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internationale |
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| date de publication : |
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05/2007 |
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| volume : |
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24 |
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| numéro : |
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5 |
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| page, identifiant, ... : |
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599-608 |
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| mots-clés auteur : |
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Environnement – asthme – asthme sévère – allergie |
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| Descripteur(s) MeSH : |
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Adult – Age Factors – Asthma – Biological Markers – Body Mass Index – Bronchial Hyperreactivity – Case-Control Studies – Child – Contraceptives – Oral – Environment – Eosinophils – Epidemiologic Studies – Female – France – Humans – Hypersensitivity – Immediate – Immunoglobulin E – Male – Menarche – Menopause – Phenotype – Premenstrual Syndrome – Risk Factors – Smoking |
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| contrat, financement : |
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Convention INSERM-MSD, réseau INSERM de recherche clinique (489012) et de santé publique (493009), Ministère de la santé, Ministère de l'environnement, Direction de la Recherche Clinique du CHU de Grenoble et COMARES |
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