434 articles – 313 Notices  [english version]
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Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study.
Ferrand J.-F., Cénée S., Laurent-Puig P., Loriot M.-A., Trinchet J.-C., Degos F., Bronovicky J.-P., Pelletier G., Stücker I.
Journal of Occupational & Environmental Medicine 50, 2 (2008) 212-220 - http://www.hal.inserm.fr/inserm-00260676
(18301178)
Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study.
Jean-François Ferrand1, Sylvie Cénée1, Pierre Laurent-Puig2, Marie-Anne Loriot2, Jean-Claude Trinchet3, Françoise Degos4, Jean-Pierre Bronovicky, Gilles Pelletier5, Isabelle Stücker () 1
1 :  Epidémiologie environnementale des cancers
http://ifr69.vjf.inserm.fr/u754/
INSERM : IFR69 – Université Paris XI - Paris Sud
16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF CEDEX
France
2 :  Bases moléculaires de la réponse aux xénobiotiques
INSERM : U775 – CNRS : IFR95 – Université Paris V - Paris Descartes
Ufr Des Saints Peres 45 Rue Des Saint Peres 75006 PARIS
France
3 :  Service d'hépato-gastroentérologie
Assistance publique - Hôpitaux de Paris (AP-HP)
Hôpital Jean Verdier avenue du 14 juillet 93143 BONDY
France
4 :  Service d'hépatologie
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Beaujon – Université Paris VII - Paris Diderot
Clichy
France
5 :  Hôpital Bicêtre
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Bicêtre – Université Paris XI - Paris Sud
78, rue du Général Leclerc 94275 Le Kremlin-Bicêtre
France
OBJECTIVE:: The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations. METHODS:: This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects. RESULTS:: An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0-19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8-5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years. CONCLUSIONS:: Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
Sciences du Vivant/Santé publique et épidémiologie
Anglais
1076-2752

Articles dans des revues avec comité de lecture
10.1097/JOM.0b013e31815d88e2
Journal of Occupational & Environmental Medicine
internationale
02/2008
50
2
212-220