PMID: identifiant
de la référence Pubmed : |
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 (17923819)  |
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| titre : |
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Familial history of cancer and childhood acute leukemia: a French population-based case-control study. |
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| auteur(s) : |
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Mahaut Ripert1, Florence Menegaux ( ) 1, Yves Perel2, Françoise Méchinaud3, Emmanuel Plouvier4, Virginie Gandemer5, Patrick Lutz6, Jean-Pierre Vannier7, Jean-Pierre Lamagnére8, Geneviève Margueritte9, Patrick Boutard10, Alain Robert11, Corinne Armari-Alla12, Martine Munzer13, Frédéric Millot14, Lionel De Lumley15, Christian Berthou16, Xavier Rialland17, Brigitte Pautard18, Jacqueline Clavel1 |
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| laboratoire : |
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| résumé : |
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A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia. The history of cancer in the relatives of 472 cases was compared with that of 567 population-based controls. Recruitment was frequency matched on age, sex and region. The familial history of cancer in each child's relatives was reported by the mother in response to a standardized self-administered questionnaire. A familial history of solid tumor in first or second-degree relatives was associated with an increased risk of acute lymphoblastic leukemia (odds ratio (OR)=1.6 [95% confidence interval, 1.2-2.1]), while a familial history of hematopoietic malignancies in first or second-degree relatives was associated with an increased risk of acute myeloid leukemia (OR=4.3 [1.4-13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1-2.0] for one relative and OR=2.3 [1.3-3.8] for two relatives or more; Ptrend<0.0001). Significant associations between childhood acute leukemia and familial history of genital cancers and brain tumor were also observed (OR=2.7 [1.2-5.8] and OR=10.7 [1.3-86], respectively). This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0959-8278 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1097/01.cej.0000243849.82232.cb |
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| journal : |
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| European Journal of Cancer Prevention (Eur J Cancer Prev) |
| Publisher |
Lippincott, Williams & Wilkins |
| ISSN |
0959-8278 |
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| Audience : |
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internationale |
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| date de publication : |
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10/2007 |
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| volume : |
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16 |
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| numéro : |
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5 |
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| page, identifiant, ... : |
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466-70 |
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| mots-clés auteur : |
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case-control study – childhood – leukemia – familial history |
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| Descripteur(s) MeSH : |
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Acute Disease – Adolescent – Case-Control Studies – Child – Preschool – Family – Female – Humans – Infant – Newborn – Leukemia – Male – Neoplasms |
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