PMID: identifiant
de la référence Pubmed : |
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 (17954799)  |
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| titre : |
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Personal history of endometriosis and risk of cutaneous melanoma in a large prospective cohort of French women. |
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| auteur(s) : |
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Marina Kvaskoff1, Sylvie Mesrine1, Agnès Fournier1, Marie-Christine Boutron-Ruault1, Françoise Clavel-Chapelon ( ) 1 |
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| laboratoire : |
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| résumé : |
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BACKGROUND: An association between melanoma and endometriosis has been reported, but most findings relied on case-control studies or a limited number of melanoma cases, and therefore the available evidence is weak. Moreover, the effect of other benign gynecological diseases on melanoma risk is unknown. METHODS: We prospectively studied data from the Etude Epid?ologique aupr?de femmes de la Mutuelle G?rale de l'Education Nationale cohort, which includes 98 995 French women, insured by a national health scheme mostly covering teachers, aged 40 to 65 years at inclusion. Data on history of endometriosis and other benign gynecological diseases were regularly collected, starting in 1990. Relative risks and 95% confidence intervals were computed using Cox proportional hazards regression models. RESULTS: During 12 years of follow-up, 363 melanoma cases were ascertained among 91 965 subjects. A history of endometriosis (n = 5949) was significantly associated with a higher risk of melanoma (relative risk, 1.62; 95% confidence interval, 1.15-2.29). There was also a significantly increased risk among women with a history of fibroma (n = 24 375), compared with those who had no such history (relative risk, 1.33; 95% confidence interval, 1.06-1.67). A history of ovarian cyst, uterine polyp, breast adenoma/fibroadenoma, or breast fibrocystic disease was not significantly associated with risk. CONCLUSIONS: These data provide the strongest evidence to date of a positive association between a history of endometriosis and melanoma risk. The association between fibroma and melanoma, which has not been previously described, warrants further investigation. |
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| domaine : |
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0003-9926 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1001/archinte.167.19.2061 |
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| journal : |
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Archives of Internal Medicine |
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| Audience : |
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internationale |
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| date de publication : |
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22/10/2007 |
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| volume : |
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167 |
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| numéro : |
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19 |
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| page, identifiant, ... : |
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2061-5 |
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| contrat, financement : |
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This study was supported by the French League Against Cancer, the European Community, the 3M Company, the Mutuelle Générale de l'Education Nationale, the Institut Gustave Roussy, the Institut National de la Santé et de la Recherche Médicale, and the Fondation de France (Ms Kvaskoff). |
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