PMID: identifiant
de la référence Pubmed : |
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 (17625430) |
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| titre : |
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Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study. |
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| auteur(s) : |
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Wolfgang Ahrens ( ) 1, 2, Antje Timmer2, 3, Mogens Vyberg4, Tony Fletcher5, Pascal Guénel6, Enzo Merler7, Franco Merletti8, Maria Morales9, 10, Håkan Olsson11, Jorn Olsen12, Lennart Hardell13, Linda Kaerlev12, 14, Nicole Raverdy15, Elsebeth Lynge16 |
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| laboratoire : |
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| résumé : |
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OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0954-691X |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1097/01.meg.0000243876.79325.a1 |
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| journal : |
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European Journal of Gastroenterology & Hepatology |
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| Audience : |
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internationale |
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| date de publication : |
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08/2007 |
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| volume : |
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19 |
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| numéro : |
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8 |
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| page, identifiant, ... : |
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623-30 |
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| mots-clés auteur : |
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alcohol consumption – biliary tract carcinoma – case-control study – epidemiology – etiology – gallbladder carcinoma – medical history – men – obesity – smoking. |
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