PMID: identifiant
de la référence Pubmed : |
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 (12462548)  |
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| titre : |
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Cumulative number of menstrual cycles and breast cancer risk: results from the E3N cohort study of French women. |
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| auteur(s) : |
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Françoise Clavel-Chapelon ( ) 1 |
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| laboratoire : |
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| résumé : |
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OBJECTIVE: To examine the relationship between breast cancer risk and the cumulative number of cycles before a first full-term pregnancy (FTP) and lifetime, taking age at menarche and at onset of regular cycling, periodicity and regularity of cycles, duration of periods of pregnancy, and lactation, oral contraceptive (OC) use, and age at menopause into account. METHODS: The data were taken from the E3N prospective cohort study of women aged 40-65 years in 1990. A total of 1718 breast cancer cases were identified during the 579,525 person-years of follow-up. RESULTS: There was a highly significant linear relationship between breast cancer risk and both the cumulative number of cycles before a first FTP (p for trend < 0.0001) and lifetime (p for trend < 0.001), with multivariate relative risk (RR) of a similar magnitude for both variables. Compared to women with a lifetime number of cycles <402 (< or =30 years), the RR for those with a lifetime total of 403-441, 442-480, 481-520, and > or =521 cycles were 0.95 (0.75-1.21), 1.21 (0.97-1.52), 1.23 (0.96-1.58), and 1.60 (1.25-2.04), respectively. Results restricted to never OC users were similar. CONCLUSIONS: Further investigation is needed to clarify whether the underlying factor is repeated exposure to fluctuating hormones, the number of anovular/ovular cycles, or the relative importance of the follicular and luteal phases. |
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| domaine : |
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0957-5243 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| journal : |
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Cancer Causes Control |
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| date de publication : |
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11/2002 |
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| volume : |
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13 |
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| numéro : |
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9 |
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| page, identifiant, ... : |
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831-8 |
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| Descripteur(s) MeSH : |
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Adult – Aged – Breast Neoplasms – Cohort Studies – Confidence Intervals – Confounding Factors (Epidemiology) – Female – France – Humans – Menstrual Cycle – Middle Aged – Multivariate Analysis – Proportional Hazards Models – Prospective Studies – Questionnaires – Risk Fa |
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| contrat, financement : |
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The E3N study is supporting financially by the French League against Cancer, the European Community, the 3M Company, the Mutuelle Générale de l'Education Nationale, the Institut Gustave-Roussy, and the Institut National de la Santé et de la Recherche Médicale. |
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