PMID: identifiant
de la référence Pubmed : |
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 (17446796) |
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| titre : |
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Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study. |
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| auteur(s) : |
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The Decode Study Group ( ) 1, decode study group Collaboration(s) |
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| laboratoire : |
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| titre abrégé : |
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Metabolic syndrome and cardiovascular risk scores |
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| résumé : |
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BACKGROUND: It is not known whether the metabolic syndrome detects further individuals at high risk of death from cardiovascular disease (CVD), beyond those identified by a conventional cardiovascular risk score. DESIGN: A prospective study. METHODS: A total of 2790 men without diabetes, aged 50-69 years from seven population-based European cohorts participating in the DECODE Study, were followed for CVD mortality over 10 years. RESULTS: Some 51% of the men had an estimated 10-year risk of fatal CVD under 5%, using the European SCORE project equation, and 22% of them had the metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel III. In the low-risk men, the hazards ratio for fatal CVD, after adjusting for age and study centre, was 2.71 (1.33-5.51) for men with the syndrome (P<0.01) compared with men without the syndrome. A large waist circumference (>102 cm) carried an odds ratio of 2.24 (1.05-4.76) in the low CVD risk men. CONCLUSIONS: Men with a low cardiovascular risk score and the metabolic syndrome had a significantly higher risk of fatal CVD than those without the syndrome. The use of the metabolic syndrome in clinical practice is thus justified in men, but waist circumference provided a simpler diagnostic tool with similar fatal CVD risk in these low-risk men. A large waist circumference could be used for prescreening, and could be included in CVD risk scores. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1741-8267 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1097/01.hjr.0000230107.78524.da |
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| journal : |
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European Journal of Cardiovascular Prevention & Rehabilitation |
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| Audience : |
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internationale |
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| date de publication : |
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04/2007 |
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| volume : |
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14 |
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| numéro : |
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2 |
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| page, identifiant, ... : |
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192-9 |
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| mots-clés auteur : |
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cardiovascular diseases – epidemiology – obesity – risk factors |
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