PMID: identifiant
de la référence Pubmed : |
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 (14710221)  |
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| titre : |
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Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia. |
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| auteur(s) : |
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Nathalie Jourdan-Da Silva1, Yves Perel2, Françoise Méchinaud3, Emmanuel Plouvier4, Virginie Gandemer5, Patrick Lutz6, Jean-Paul Vannier7, Jean-Pierre Lamagnere8, Geneviève Margueritte9, Patrick Boutard10, Alain Robert11, Corinne Armari-Alla12, Martine Munzer13, Frédéric Millot14, Lionel De Lumley15, Christian Berthou16, Xavier Rialland17, Brigitte Pautard18, Denis Hémon1, Jacqueline Clavel1 |
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| laboratoire : |
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| résumé : |
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The objective of the present study was to investigate the role of early common infections and perinatal characteristics in the aetiology of childhood common leukaemia. A case-control study was conducted from 1995 to 1998 in France, and included 473 incident cases of acute leukaemia (AL) (408 acute lymphoblastic leukaemia (ALL), 65 acute myeloid leukaemia (AML) age-, sex- and region-matched with 567 population-based controls. Data on the medical history of the child and his/her environment were collected using self-administered questionnaires. Analyses were conducted using nonconditional logistic regression. A slight negative association with early infections was observed (OR=0.8; 95% CI (0.6-1.0)). The association was stronger for early gastrointestinal infections. Early day-care was found to be associated with a decreased risk of AL (OR=0.6; 95% CI (0.4-0.8) and OR=0.8; 95% CI (0.5-1.2) for day-care starting before age 3 months and between 3 and 6 months, respectively). No association with breast-feeding was observed, irrespective of its duration. A birth order of 4 or more was associated with a significantly increased risk of AL (OR=2.0; 95% CI (1.1-3.7) with ALL). A history of asthma was associated with a decreased risk of ALL (OR 0.5; 95% CI (0.3-0.90). Although the results regarding birth order and breast-feeding do not fit with Greaves' hypothesis, the study supports the hypothesis that early common infections may play a protective role in the aetiology of childhood leukaemia, although this effect was not more marked for common ALL. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0007-0920 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1038/sj.bjc.6601384 |
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| journal : |
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Br J Cancer |
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| date de publication : |
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2004 |
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| volume : |
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90 |
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| page, identifiant, ... : |
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139-45 |
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| Descripteur(s) MeSH : |
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Acute Disease – Age Factors – Asthma – Birth Order – Breast Feeding – Case-Control Studies – Child Day Care Centers – Female – France – Humans – Infant – Newborn – Diseases – Infection – Leukemia – Lymphocytic – Acute – Myeloid – Male – Me |
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