PMID: identifiant
de la référence Pubmed : |
 |
 (16674960) |
|
| titre : |
|
Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: The DESIR study. |
|
| auteur(s) : |
|
Robyn Tapp1, 2, Beverley Balkau1, 3, Jonathan Shaw2, 4, Paul Valensi5, Martine Cailleau6, Eveline Eschwège1, 3, The DESIR Study Group Collaboration(s) |
|
| laboratoire : |
|
|
|
| résumé : |
|
AIMS: We determined the 6-year incidence of peripheral arterial disease (PAD) in a French population and assessed the association of glucose metabolism, smoking, cardiovascular risk factors and physical activity with incident PAD. METHODS: Participants from the French Data from a Epidemiological Study on the Insulin Resistance Syndrome (DESIR) were studied. Participants analysed were 30-65 years (at baseline) and had complete data (n=3805) after 6 years of follow-up. Diabetes was diagnosed according to the 1999 WHO criteria on the basis of fasting plasma glucose results or previous diagnosis of diabetes mellitus. The ankle brachial pressure index (ABPI) and a claudication question were used to classify PAD. RESULTS: The 6-year incidence of PAD (defined by ABPI<0.9 and or claudication present) among those with normal fasting glucose (NFG) and free of PAD at baseline was 5.1%. Among those with impaired fasting glucose (IFG) at baseline the incidence of PAD was 4.9% and among those with diabetes mellitus at baseline the incidence of PAD was 9.8%. The incidence of PAD among those who maintained NFG over 6 years was 4.7% and among those who progressed to diabetes over 6 years was 10.2%. Those who progressed from NFG or IFG to diabetes over 6 years were twice as likely to develop PAD compared to those who maintained NFG over 6 years, after adjustment for age and sex (OR (95% CI), 2.22 (1.12-4.42)). Independent risk factors for incident PAD using baseline population characteristics were diabetes (OR (95% CI) 2.11 (1.25-3.55)), systolic BP 122-135mmHg 1.06 (0.70-1.60), >135mmHg 1.54 (1.04-2.27) and current smoking 1.60 (1.10-2.34) after multivariate adjustment for age, sex, cholesterol, triglycerides and waist circumference. CONCLUSIONS: This French study shows that those who progress to diabetes are twice as likely to develop PAD, compared to those who maintain NFG. Peripheral arterial disease is a treatable condition and more aggressive management of atherosclerotic risk factors could reduce the numbers of people who develop PAD. |
|
| domaine : |
|
|
|
langue du texte
intégral : |
|
Anglais |
|
| ISSN : |
|
0021-9150 |
|
|
| type de publication : |
|
Articles dans des revues avec comité de lecture |
|
| DOI : |
|
10.1016/j.atherosclerosis.2006.02.017 |
|
| journal : |
|
| Atherosclerosis (Atherosclerosis) |
| Publisher |
Elsevier |
| ISSN |
0021-9150 |
|
|
| date de publication : |
|
01/2007 |
|
date de publication
électronique : |
|
03/05/2006 |
|
| volume : |
|
190 |
|
| numéro : |
|
1 |
|
| page, identifiant, ... : |
|
84-9 |
|
|
